TERT-BUTYL N-(BENZYLOXY)CARBAMATE

Base Information

• Chemical Name: TERT-BUTYL N-(BENZYLOXY)CARBAMATE
• CAS No.: 79722-21-7
• Molecular Formula: C12H17NO3
• Molecular Weight: 223.272
• Hs Code.: 29280000
• Mol file: 79722-21-7.mol

Synonyms:tert-Butyl benzyloxycarbamate;

Chemical Property of TERT-BUTYL N-(BENZYLOXY)CARBAMATE

Chemical Property:

• Melting Point: 45-47 °C
• Refractive Index: 1.505
• PSA: 47.56000
• Density: 1.078 g/cm³
• LogP: 3.03380
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

tert-Butyl N-(Benzyloxy)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: tert-Butyl N-(benzyloxy)carbamate was used in the preparation of seven-membered cyclic hydroxamic acids. It may be used in the synthesis of 2-(N-formyl-N-hydroxyamino) ethylphosphonate (IPP). tert-Butyl N-(Benzyloxy)carbamate has been used in the synthesis of Deferoxamine Mesylate (D228980), an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients

Technology Process of TERT-BUTYL N-(BENZYLOXY)CARBAMATE

There total 11 articles about TERT-BUTYL N-(BENZYLOXY)CARBAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

di-tert-butyl dicarbonate (24424-99-5) + O-benzylhydoxylamine hydrochloride (2687-43-6) → tert-butyl N-(benzyloxy)carbamate (79722-21-7)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water; at 0 ℃; for 3h;

DOI:10.1021/jo971254e

Reference yield: 99.0%

N-benzyloxyamine (622-33-3) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl N-(benzyloxy)carbamate (79722-21-7)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 20h;

Reference yield: 98.0%

di-tert-butyl dicarbonate (24424-99-5) + O-benzylhydoxylamine hydrochloride (2687-43-6) + sodium carbonate (497-19-8) → tert-butyl N-(benzyloxy)carbamate (79722-21-7)

Guidance literature:

In 1,4-dioxane; water;

upstream raw materials:

N-benzyloxyamine

di-tert-butyl dicarbonate

N-benzylhydroxylamine hydrochloride

O-benzylhydoxylamine hydrochloride

Downstream raw materials:

diethyl hydrazodicarboxylate

Triphenylphosphine oxide

dimethyl (E)-{3-[(N-benzyloxy-N-tert-butoxycarbonyl)amino]-1-propenyl}phosphonate

tert-butyl (benzyloxy)(5-cyanopentyl)carbamate

Refernces

• 1、 Lee, Jaeyong,Ban, Jeong Woo,Kim, Jeongseok,Yang, Sehun,Lee, Geumwoo,Dhorma, Lama Prema,Kim, Mi-Hyun,Ha, Min Woo,Hong, Suckchang,Park, Hyeung-Geun. "Asymmetric Phase-Transfer Catalytic aza-Michael Addition to Cyclic Enone: Highly Enantioselective and Diastereoselective Synthesis of Cyclic 1,3-Aminoalcohols". supporting information. p. 1647 - 1651. Retrieved 2022/03/03.
• 2、 -. "NOVEL ALKENYL AND BETA-SUBSTITUTED PHOSPHONATES AS ANTIMICROBIAL AGENTS". Paragraph 0088; 0092; 0116; 0162. . Retrieved 2019/01/17.