2-Hydroxy-4-methylnicotinic acid

Base Information

• Chemical Name: 2-Hydroxy-4-methylnicotinic acid
• CAS No.: 38076-81-2
• Molecular Formula: C7H7 N O3
• Molecular Weight: 153.14
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90495840
• Wikidata: Q72485597
• Mol file: 38076-81-2.mol

Synonyms:38076-81-2;2-Hydroxy-4-methylnicotinic acid;2-Hydroxy-4-methyl-nicotinic acid;2-hydroxy-4-methylpyridine-3-carboxylic acid;2-Hydroxy-4-methylpridine-3-carboxylic acid;4-METHYL-2-OXO-1H-PYRIDINE-3-CARBOXYLIC ACID;MFCD09033815;4-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid;3-Pyridinecarboxylicacid, 1,2-dihydro-4-methyl-2-oxo-;2-Hydroxy-4-methylnicotinicacid;1,2-dihydro-4-methyl-2-oxo-3-pyridinecarboxylic acid;SCHEMBL2223763;SCHEMBL10766873;AMY6389;DTXSID90495840;XTLDPQQUIMHNNC-UHFFFAOYSA-N;AKOS006332469;AKOS015867047;AS-5257;SB53832;SY147931;CS-0169237;FT-0682789;E78505;EN300-128295;A873928;2-HYDROXY-4-METHYL-3-PYRIDINECARBOXYLICACID;4-methyl-2-oxo-1,2-dihydro-3-pyridinecarboxylic acid;Z1623872049

Chemical Property of 2-Hydroxy-4-methylnicotinic acid

Chemical Property:

• Vapor Pressure: 5.84E-08mmHg at 25°C
• Melting Point: 247 ºC
• Boiling Point: 424.4°C at 760 mmHg
• Flash Point: 210.5°C
• PSA: 70.42000
• Density: 1.345
• LogP: 0.79380
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 153.042593085
• Heavy Atom Count: 11
• Complexity: 275

Purity/Quality:

98%min ^*data from raw suppliers

2-Hydroxy-4-methyl-nicotinicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=O)NC=C1)C(=O)O

Technology Process of 2-Hydroxy-4-methylnicotinic acid

There total 1 articles about 2-Hydroxy-4-methylnicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-hydroxy-4-methylnicotinic acid (38076-81-2)

Guidance literature:

Nitril 15, wss. HCl (S. 2408);

Reference yield:

2-hydroxy-4-methylnicotinic acid (38076-81-2) + 4-[(Z)-(4-bromophenyl)(ethoxyimino)methyl]-1-(4-methyl-4-piperidinyl)-piperidine (515881-16-0) → 4-[(Z)-(4-bromophenyl)(ethoxyimino)methyl]-1'-[(4-hydroxy-2-methyl-3-pyridinyl)carbonyl]-4'-methyl-1,4'-bipiperidine

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/jm0200815