2,4-DICHLORO-6-HYDROXYBENZALDEHYDE

Base Information

• Chemical Name: 2,4-DICHLORO-6-HYDROXYBENZALDEHYDE
• CAS No.: 78443-72-8
• Molecular Formula: C7H4Cl2O2
• Molecular Weight: 191.014
• Hs Code.: 2913000090
• Mol file: 78443-72-8.mol

Synonyms:Salicylaldehyde,4,6-dichloro- (7CI);2,4-Dichloro-6-hydroxybenzaldehyde;2-Hydroxy-4,6-dichlorobenzaldehyde;4,6-Dichloro-2-hydroxybenzaldehyde;4,6-Dichlorosalicylaldehyde;

Chemical Property of 2,4-DICHLORO-6-HYDROXYBENZALDEHYDE

Chemical Property:

• Vapor Pressure: 0.0103mmHg at 25°C
• Melting Point: 51 °C
• Refractive Index: 1.643
• Boiling Point: 255.2 °C at 760 mmHg
• Flash Point: 108.2 °C
• PSA: 37.30000
• Density: 1.547 g/cm³
• LogP: 2.51150
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Air Sensitive
• Solubility.: Sparingly Soluble (0.092 g/L) (25°C).

Purity/Quality:

99%, ^*data from raw suppliers

2,4-Dichloro-6-hydroxybenzaldehyde 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4,6-Dichlorosalicylaldehyde is used for synthesis of series of indazole derivatives for their antibacterial activity and interactions as inhibitor of DNA gyrase B.

Technology Process of 2,4-DICHLORO-6-HYDROXYBENZALDEHYDE

There total 6 articles about 2,4-DICHLORO-6-HYDROXYBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2,4-dichlorobenzaldeyhde (874-42-0) → 4,6-dichlorosalicylaldehyde (78443-72-8)

Guidance literature:

With palladium diacetate; toluene-4-sulfonic acid; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate; acetic acid; 2-Amino-4-chlorobenzoic acid; at 90 ℃; for 24h; Sealed tube;

DOI:10.1021/acs.orglett.7b02906

Reference yield: 18.0%

C23H19Cl3N2O2Pd → 4,6-dichlorosalicylaldehyde (78443-72-8)

Guidance literature:

With toluene-4-sulfonic acid; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate; acetic acid; at 90 ℃; for 24h; Sealed tube;

DOI:10.1021/acs.orglett.7b02906

Reference yield:

4-chlorosalicylaldehyde (2420-26-0) → 4,6-dichlorosalicylaldehyde (78443-72-8)

Guidance literature:

upstream raw materials:

N,N-dimethyl-formamide

4-chlorosalicylaldehyde

2,4-dichlorobenzaldeyhde

Downstream raw materials:

2,4-dichloro-6-(phenylmethoxy)benzaldehyde

2,4-Dichloro-6-phenethyloxy-benzaldehyde

2,4-Dichloro-6-(pyridin-2-ylmethoxy)-benzaldehyde

2,4-Dichloro-6-(pyridin-3-ylmethoxy)-benzaldehyde

Refernces

• 1、 Kauch, Matthias,Hoppe, Dieter. "Efficient two-step synthesis of salicylaldehydes via directed ortho-lithiation of in situ N-silylated O-aryl N-isopropylcarbamates". . p. 1575 - 1577. Retrieved 2007/10/03.
• 2、 -. "Non-metallocene compounds, method for the production thereof and use of the same for the polymerisation of olefins". . . Retrieved 2008/06/13.