(2R,3S)-1-chloro-3-dibenzylamino-4-phenyl-2-butanol sulfuric acid salt

Base Information

• Chemical Name: (2R,3S)-1-chloro-3-dibenzylamino-4-phenyl-2-butanol sulfuric acid salt
• CAS No.: 934971-01-4
• Molecular Formula: C₂₄H₂₆ClNO*H₂O₄S
• Molecular Weight: 478.009
• Mol file: 934971-01-4.mol

Synonyms:(2R,3S)-1-chloro-3-dibenzylamino-4-phenyl-2-butanol sulfuric acid salt

Chemical Property of (2R,3S)-1-chloro-3-dibenzylamino-4-phenyl-2-butanol sulfuric acid salt

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S)-1-chloro-3-dibenzylamino-4-phenyl-2-butanol sulfuric acid salt

There total 7 articles about (2R,3S)-1-chloro-3-dibenzylamino-4-phenyl-2-butanol sulfuric acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(2R,3S)-3-(Dibenzylamino)-1-chloro-4-phenylbutan-2-ol (171962-76-8) → (2R,3S)-1-chloro-3-dibenzylamino-4-phenyl-2-butanol sulfuric acid salt (934971-01-4)

Guidance literature:

With sulfuric acid; In dichloromethane; at 20 ℃; Product distribution / selectivity;

Reference yield:

(3S)-3-dibenzylamino-1-chloro-2-oxo-4-phenylbutane (171815-94-4) → (2R,3S)-1-chloro-3-dibenzylamino-4-phenyl-2-butanol sulfuric acid salt (934971-01-4)

Guidance literature:

(3S)-3-dibenzylamino-1-chloro-2-oxo-4-phenylbutane; With sodium tetrahydroborate; ethanol; at -3 ℃; for 0.5h;

With sulfuric acid;

Reference yield:

C26H27NO4 → (2R,3S)-1-chloro-3-dibenzylamino-4-phenyl-2-butanol sulfuric acid salt (934971-01-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 5 °C / Inert atmosphere

2: hydrogenchloride / water / 5 °C

3: sodium tetrahydroborate; ethanol / 0.5 h / -3 °C

With hydrogenchloride; sodium tetrahydroborate; ethanol; In water;

upstream raw materials:

(2R,3S)-3-(Dibenzylamino)-1-chloro-4-phenylbutan-2-ol

(3S)-3-dibenzylamino-1-chloro-2-oxo-4-phenylbutane

L-phenylalanine

N,N-dibenzyl-L-phenylalanine benzyl ester

Downstream raw materials:

(2R,3S)-1-chloro-3-amino-4-phenyl-2-butanol sulfuric acid salt

benzyl alcohol

Refernces

• 1、 -. "Production method of aminochlorohydrin sulfate". Page/Page column 18-19. . Retrieved 2010/11/26.