4-methoxy-α-phenyl-β-methylstyrene

Base Information

• Chemical Name: 4-methoxy-α-phenyl-β-methylstyrene
• CAS No.: 19810-20-9
• Molecular Formula: C₁₆H₁₆O
• Molecular Weight: 224.302
• Mol file: 19810-20-9.mol

Synonyms:4-methoxy-α-phenyl-β-methylstyrene

Chemical Property of 4-methoxy-α-phenyl-β-methylstyrene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methoxy-α-phenyl-β-methylstyrene

There total 13 articles about 4-methoxy-α-phenyl-β-methylstyrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

phenylmagnesium bromide (100-58-3) + 4-Methoxypropiophenone (121-97-1) → 4-methoxy-α-phenyl-β-methylstyrene (19810-20-9)

Guidance literature:

4-Methoxypropiophenone; With aluminium(III) triflate; In dichloromethane; at -30 ℃; for 0.5h; Inert atmosphere;

phenylmagnesium bromide; In diethyl ether; dichloromethane; at -30 - 20 ℃; for 24h; Inert atmosphere;

DOI:10.1055/s-0035-1561401

Reference yield: 95.0%

1-bromo-4-methoxy-benzene (104-92-7) + 3-ethyl-3-phenyl-3H-diazirine (1235751-66-2) → 4-methoxy-α-phenyl-β-methylstyrene (19810-20-9)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triethylamine; XPhos; In 1,2-dichloro-ethane; at 110 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1021/ol102434v

Reference yield: 93.0%

1-bromo-4-methoxy-benzene (104-92-7) + propiophenone N-tosylhydrazone (17336-66-2) → 4-methoxy-α-phenyl-β-methylstyrene (19810-20-9)

Guidance literature:

With bis(triphenylphosphine)palladium(II) dichloride; lithium tert-butoxide; In 1,4-dioxane; at 100 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jo301987c

upstream raw materials:

ethylmagnesium iodide

4-Methoxybenzophenone

diethyl ether

ethylmagnesium bromide

Downstream raw materials:

2-methyl-3-(4-methoxybenzene)-1H-indole

(S)-2-(4-methoxyphenyl)-1-phenylpropan-1-one

(E)-1-methoxy-4-(3,3,3-trifluoro-2-methyl-1-phenyl-1-propenyl)benzene

(Z)-1-methoxy-4-(3,3,3-trifluoro-2-methyl-1-phenyl-1-propenyl)benzene

Refernces

• 1、 Kortman, Gregory D.,Hull, Kami L.. "Copper-Catalyzed Hydroarylation of Internal Alkynes: Highly Regio- and Diastereoselective Synthesis of 1,1-Diaryl, Trisubstituted Olefins". . p. 6220 - 6224. Retrieved 2017/09/15.
• 2、 Du, Wenbin,Lai, Junshan,Tian, Lixia,Xie, Xingang,She, Xuegong,Tang, Shouchu. "Metal-free Mizoroki-Heck type reaction: A radical oxidative coupling reaction of 2-chloro-dithiane with substituted olefins". supporting information. p. 14017 - 14020. Retrieved 2015/01/16.