2-HYDROXYMETHYL-BENZOIC ACID METHYL ESTER

Base Information

• Chemical Name: 2-HYDROXYMETHYL-BENZOIC ACID METHYL ESTER
• CAS No.: 41150-46-3
• Molecular Formula: C9H10O3
• Molecular Weight: 166.177
• Hs Code.: 2918199090
• Mol file: 41150-46-3.mol

Synonyms:2-Methoxycarbonylbenzyl alcohol;o-(Methoxycarbonyl)benzyl alcohol;Methyl 2-(hydroxymethyl)benzoate;2-Hydroxymethyl-benzoic acid methyl ester;

Chemical Property of 2-HYDROXYMETHYL-BENZOIC ACID METHYL ESTER

Chemical Property:

• Boiling Point: 302.251 °C at 760 mmHg
• PKA: 14.08±0.10(Predicted)
• Flash Point: 133.143 °C
• PSA: 46.53000
• Density: 1.177 g/cm³
• LogP: 0.96550
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-(hydroxymethyl)benzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-HYDROXYMETHYL-BENZOIC ACID METHYL ESTER

There total 9 articles about 2-HYDROXYMETHYL-BENZOIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methanol (67-56-1) + 2-benzofuran-1(3H)-one (87-41-2) → methyl 2-hydroxymethylbenzoate (41150-46-3)

Guidance literature:

With amberlyst-15; for 26h;

DOI:10.1080/00397919408010590

Reference yield: 81.0%

phthalic acid 1-(4,6-dimethoxy-[1,3,5]triazin-2-yl) ester 2-methyl ester → methyl 2-hydroxymethylbenzoate (41150-46-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In 1,2-dimethoxyethane; at 20 ℃; for 3h; under 3800 Torr;

DOI:10.1021/jo991112f

Reference yield:

C9H10O3*C5H5N*Br3H → methyl 2-hydroxymethylbenzoate (41150-46-3) + pyridinium hydrobromide perbromide (39416-48-3,91113-93-8)

Guidance literature:

In acetic acid; at 19.9 ℃; Equilibrium constant; Thermodynamic data; ΔH, ΔS, ΔG, var. temp.;

upstream raw materials:

methanol

1-ethoxy-1,3-dihydroisobenzofuran-1-ylium borofluorate

Monomethyl phthalate

2-benzofuran-1(3H)-one

Downstream raw materials:

methyl o-formylbenzoate

2-(2-(methoxycarbonyl)phenyl)acetic acid

2-hydroxymethyl-benzoic acid hydrazide

2-benzofuran-1(3H)-one

Refernces

• 1、 Allen, Caroline R.,Brown, Drew K.,Potts, Jessica L.,Ji, Chang. "Electrochemical reduction of methyl 2-bromomethylbenzoate at carbon cathodes in dimethylformamide containingwater". . p. G3069-G3072. Retrieved 2013/07/05.
• 2、 Narasimhan,Swarnalakshmi,Balakumar. "Reduction of carboxylic acids by tetraalkyl ammonium borohydride". . p. 941 - 946. Retrieved 2007/10/03.