2-chloropyridine-3-sulfonyl Chloride

Base Information

• Chemical Name: 2-chloropyridine-3-sulfonyl Chloride
• CAS No.: 6684-06-6
• Molecular Formula: C5H3Cl2NO2S
• Molecular Weight: 212.056
• Hs Code.: 2933399090
• European Community (EC) Number: 682-569-0
• DSSTox Substance ID: DTXSID40436900
• Nikkaji Number: J1.184.730G
• Wikidata: Q72458588
• Mol file: 6684-06-6.mol

Synonyms:2-chloropyridine-3-sulfonyl Chloride;6684-06-6;2-Chloro-pyridine-3-sulfonyl chloride;2-Chloropyridine-3-sulfonylchloride;2-chloro-3-pyridinesulfonyl chloride;2-chloropyridine-3-sulphonyl chloride;3-Pyridinesulfonyl chloride, 2-chloro-;MFCD05664916;2-chloranylpyridine-3-sulfonyl chloride;2-Chloro-3-pyridylsulfonyl chloride;SCHEMBL349118;DTXSID40436900;2-Chloro-3-chlorosulfonylpyridine;MFJSIQDQIZEVJX-UHFFFAOYSA-N;STL112407;AKOS000141451;AC-1815;SB38215;2-Chloro-3-pyridinesulfonic acid chloride;CS-0051922;FT-0601824;EN300-31968;2-chloro-pyridine-3-sulfonyl chloride, AldrichCPR;4T-0059;A801610;A835563;A857885;AN-652/43410820;J-509166;Not available;2-CHLORO-PYRIDINE-3-SULFONYL CHLORIDE;Z255149920

Chemical Property of 2-chloropyridine-3-sulfonyl Chloride

Chemical Property:

• Vapor Pressure: 0.00425mmHg at 25°C
• Melting Point: 42-43 °C
• Refractive Index: 1.544
• Boiling Point: 324.52 °C at 760 mmHg
• PKA: -3.73±0.10(Predicted)
• Flash Point: 150.065 °C
• PSA: 55.41000
• Density: 1.615 g/cm³
• LogP: 2.74330
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 210.9261549
• Heavy Atom Count: 11
• Complexity: 223

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-pyridine-3-sulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)Cl)S(=O)(=O)Cl

Technology Process of 2-chloropyridine-3-sulfonyl Chloride

There total 1 articles about 2-chloropyridine-3-sulfonyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-3-aminopyridine (6298-19-7) → 2,3-dichloro-pyridine (2402-77-9) + 3,3'-dithiobis(2-chloropyridine) (69212-33-5) + 2-chloro-3-pyridinesulfonyl chloride (6684-06-6) + 2-chloropyridine-3-sulfonic acid (6602-56-8) + 3,3'-sulfonylbis(2-chloropyridine)

Guidance literature:

2-chloro-3-aminopyridine; With hydrogenchloride; acetic acid; sodium nitrite; In water; at 0 ℃;

With sulfur dioxide; water; acetic acid; copper(l) chloride; at 0 ℃;

DOI:10.1021/op9000862

Reference yield: 92.0%

benzamidine monohydrochloride (1670-14-0) + 2-chloro-3-pyridinesulfonyl chloride (6684-06-6) → N3-[1-amino-1-phenylmethylidene]-2-chloro-3-pyridinesulfonamide

Guidance literature:

With potassium hydroxide; In dichloromethane; water; at 0 - 20 ℃; for 8h;

DOI:10.1002/jhet.1029

Reference yield: 91.0%

2-chloro-3-pyridinesulfonyl chloride (6684-06-6) + dibenzylamine (103-49-1) → N,N-dibenzyl-2-chloropyridine-3-sulfonamide

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 25 ℃; for 16h; Inert atmosphere;

DOI:10.1039/d0md00165a

upstream raw materials:

2-chloro-3-aminopyridine

Downstream raw materials:

4-(2-chloropyridin-3-ylsulfonyl)morpholine

2-chloro-3-pyridinylsulfonamide

2-chloro-N-(2-nitrophenyl)-3-pyridinesulfonamide

2-chloro-N-(4-chloro-2-nitrophenyl)-3-pyridinesulfonamide

Refernces