2-(Diethoxymethyl)oxirane

Base Information

• Chemical Name: 2-(Diethoxymethyl)oxirane
• CAS No.: 13269-77-7
• Molecular Formula: C7H14O3
• Molecular Weight: 146.186
• Hs Code.: 2910900090
• European Community (EC) Number: 623-351-7
• DSSTox Substance ID: DTXSID50404998
• Nikkaji Number: J801.478G
• Mol file: 13269-77-7.mol

Synonyms:2-(diethoxymethyl)oxirane;13269-77-7;Glycidaldehyde diethyl acetal;glycidaldehyde diethylacetal;Oxirane, 2-(diethoxymethyl)-;MFCD07776142;Oxirane, (diethoxymethyl)-;2-(diethoxy-methyl)-oxirane;SCHEMBL2147510;AMY7498;DTXSID50404998;QIQQWSQARNQPLP-UHFFFAOYSA-N;Glycidaldehyde diethyl acetal, 90%;AKOS015901289;CS-W018229;AS-15804;SY100504;FT-0659032;EN300-42021;A806479;J-006212;Z425450206

Chemical Property of 2-(Diethoxymethyl)oxirane

Chemical Property:

• Vapor Pressure: 0.757mmHg at 25°C
• Refractive Index: n20/D 1.414(lit.)
• Boiling Point: 190.3 °C at 760 mmHg
• Flash Point: 60.4 °C
• PSA: 30.99000
• Density: 1.028 g/cm³
• LogP: 0.78430
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 146.094294304
• Heavy Atom Count: 10
• Complexity: 88.9

Purity/Quality:

98% ^*data from raw suppliers

glycidaldehyde diethylacetal ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 10-37/38-41
• Safety Statements: 16-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(C1CO1)OCC

Technology Process of 2-(Diethoxymethyl)oxirane

There total 7 articles about 2-(Diethoxymethyl)oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3,3-diethoxypropane-1,2-diol (10487-05-5) → 2,3-epoxy-1,1-diethoxypropane (13269-77-7)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In benzene; Ambient temperature;

DOI:10.1016/S0968-0896(99)00065-6

Reference yield: 70.0%

acrylaldehyde diethyl acetal (3054-95-3) → 2,3-epoxy-1,1-diethoxypropane (13269-77-7)

Guidance literature:

With dihydrogen peroxide; potassium hydrogencarbonate; benzonitrile;

DOI:10.1016/0040-4039(95)01678-B

Reference yield:

acrylaldehyde diethyl acetal (3054-95-3) → 2,3-epoxy-1,1-diethoxypropane (13269-77-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / KMnO₄ / H₂O / 1.) room temperature, 3 h, 2.) reflux, 1 h

2: 78 percent / DEAD, Ph₃P / benzene / Ambient temperature

With potassium permanganate; triphenylphosphine; diethylazodicarboxylate; In water; benzene;

DOI:10.1016/S0968-0896(99)00065-6

upstream raw materials:

3,3-diethoxy-2-chloro-propan-1-ol

acrylaldehyde diethyl acetal

3,3-diethoxypropane-1,2-diol

(+/-)-glyceraldehyde diethyl acetal 3-O-mesylate

Downstream raw materials:

C₁₅H₂₄O₃

C₁₆H₂₆O₃

C₁₅H₂₄O₃

C₁₄H₂₁ClO₃

Refernces

• 1、 Charmantray, Franck,Dellis, Philippe,Helaine, Virgil,Samreth, Soth,Hecquet, Laurence. "Chemoenzymatic synthesis of 5-thio-D-xylopyranose". . p. 5526 - 5532. Retrieved 2006.
• 2、 Page, Patrick,Blonski, Casimir,Perie, Jacques. "Synthesis of phosphono analogues of dihydroxyacetone phosphate and glyceraldehyde 3-phosphate". . p. 1403 - 1412. Retrieved 2007/10/03.