3-Fluoro-5-methoxybenzyl bromide

Base Information

• Chemical Name: 3-Fluoro-5-methoxybenzyl bromide
• CAS No.: 914637-29-9
• Molecular Formula: C₈H₈BrFO
• Molecular Weight: 219.053
• Hs Code.: 2909309090
• Mol file: 914637-29-9.mol

Synonyms:1-(bromomethyl)-3-fluoro-5-methoxybenzene;

Chemical Property of 3-Fluoro-5-methoxybenzyl bromide

Chemical Property:

• Vapor Pressure: 0.13mmHg at 25°C
• Boiling Point: 225℃
• Flash Point: 109℃
• PSA: 9.23000
• Density: 1.488
• LogP: 2.72920

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Fluoro-5-methoxybenzylbromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Fluoro-5-methoxybenzyl bromide

There total 3 articles about 3-Fluoro-5-methoxybenzyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(3-fluoro-5-methoxyphenyl)methanol (914637-27-7) → 1-(bromomethyl)-3-fluoro-5-methoxybenzene (914637-29-9)

Guidance literature:

With hydrogen bromide; In toluene; at 20 ℃; for 72h; Reagent/catalyst; Solvent; Temperature;

Reference yield:

1-bromo-3-fluoro-5-methoxybenzene (29578-39-0) → 1-(bromomethyl)-3-fluoro-5-methoxybenzene (914637-29-9)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine / 48 h / 22502.3 Torr

2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -50 - 0 °C

3: hydrogen bromide / water; toluene / 24 h / 20 °C

With lithium aluminium tetrahydride; 1,3-bis-(diphenylphosphino)propane; hydrogen bromide; palladium diacetate; triethylamine; In tetrahydrofuran; water; toluene;

Reference yield:

C9H9FO3 → 1-(bromomethyl)-3-fluoro-5-methoxybenzene (914637-29-9)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -50 - 0 °C

2: hydrogen bromide / water; toluene / 24 h / 20 °C

With lithium aluminium tetrahydride; hydrogen bromide; In tetrahydrofuran; water; toluene;

upstream raw materials:

1-bromo-3-fluoro-5-methoxybenzene

(3-fluoro-5-methoxyphenyl)methanol

Refernces

• 1、 -. "COMPOUNDS AND USES THEREOF". Page/Page column 159-160; 185. . Retrieved 2019/10/15.