4-methyl-2-p-tolyl-5-vinylthiazole

Base Information

• Chemical Name: 4-methyl-2-p-tolyl-5-vinylthiazole
• CAS No.: 1400637-27-5
• Molecular Formula: C₁₃H₁₃NS
• Molecular Weight: 215.319
• Mol file: 1400637-27-5.mol

Synonyms:4-methyl-2-p-tolyl-5-vinylthiazole

Chemical Property of 4-methyl-2-p-tolyl-5-vinylthiazole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-methyl-2-p-tolyl-5-vinylthiazole

There total 2 articles about 4-methyl-2-p-tolyl-5-vinylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

4-methyl-5-vinylthiazole (1759-28-0) + toluene-4-sulfonic acid hydrazide (1576-35-8) → 4-methyl-2-p-tolyl-5-vinylthiazole (1400637-27-5)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); 1,10-Phenanthroline; tetrabutylammomium bromide; copper diacetate; sodium carbonate; In 1,4-dioxane; dimethyl sulfoxide; at 20 - 100 ℃; for 4.58333h; Inert atmosphere;

DOI:10.1039/c2ob26270c

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 4-methyl-2-p-tolyl-5-vinylthiazole (1400637-27-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate; water / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2: dichloro bis(acetonitrile) palladium(II); sodium carbonate; copper diacetate; tetrabutylammomium bromide; 1,10-Phenanthroline / dimethyl sulfoxide; 1,4-dioxane / 4.58 h / 20 - 100 °C / Inert atmosphere

With dichloro bis(acetonitrile) palladium(II); 1,10-Phenanthroline; tetrabutylammomium bromide; water; copper diacetate; sodium carbonate; hydrazine hydrate; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide;

DOI:10.1039/c2ob26270c

upstream raw materials:

4-methyl-5-vinylthiazole

toluene-4-sulfonic acid hydrazide

p-toluenesulfonyl chloride

Refernces