4-Bromo-2-nitrobenzaldehyde

Base Information

• Chemical Name: 4-Bromo-2-nitrobenzaldehyde
• CAS No.: 5551-12-2
• Molecular Formula: C7H4 Br N O3
• Molecular Weight: 230.018
• Hs Code.: 2913000090
• Mol file: 5551-12-2.mol

Synonyms:2-Nitro-4-bromobenzaldehyde;4-Bromo-2-nitrobenzaldehyde

Chemical Property of 4-Bromo-2-nitrobenzaldehyde

Chemical Property:

• Vapor Pressure: 0.000128mmHg at 25°C
• Melting Point: 95.0 to 99.0 °C
• Boiling Point: 334.4°Cat760mmHg
• Flash Point: 156.1°C
• PSA: 62.89000
• Density: 1.781g/cm³
• LogP: 2.69300
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-2-nitrobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn,N
• Statements: 22-36/37/38-43-50
• Safety Statements: 26-36/37-61

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Bromo-2-nitrobenzaldehyde is used along with in the synthesis of Tyrian Purple as a teaching material, from o-Nitrotoluene via 4-Bromo-2-nitrotoluene and 4-Bromo-2-nitrobenzylidene diacetate;Also, it is used as a starting material in the synthesis of heterocyclyl as HDAC3 inhibitors.

Technology Process of 4-Bromo-2-nitrobenzaldehyde

There total 23 articles about 4-Bromo-2-nitrobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-bromo-2-nitrobenzylidene diethanoate (135308-80-4) → 4-bromo-2-nitrobenzaldehyde (5551-12-2)

Guidance literature:

With sulfuric acid; In ethanol; for 1.5h; Heating;

DOI:10.1081/SCC-100107023

Reference yield: 78.0%

(4-bromo-2-nitrophenyl)methanol (22996-19-6) → 4-bromo-2-nitrobenzaldehyde (5551-12-2)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 12h;

Reference yield: 74.0%

1-[(E)-2-(4-bromo-2-nitrophenyl)vinyl]pyrrolidine → 4-bromo-2-nitrobenzaldehyde (5551-12-2)

Guidance literature:

With sodium periodate; In tetrahydrofuran; water; at 0 - 25 ℃; for 18h;

upstream raw materials:

4-amino-2-nitro-benzaldehyde-oxime

4-bromo-2-nitrobenzylidene diethanoate

1,4-dibromo-2-nitrobenzene

N,N-dimethyl-formamide

Downstream raw materials:

4-(4-bromo-2-nitro-phenyl)-4-hydroxy-butan-2-one

6,6′?di?bromo?indigo

N-<4-Brom-2-nitro-benzyliden>-4-brom-anilin

(2E)-3-(4-bromo-2-nitrophenyl)-2-(4-bromophenyl)prop-2-enoic acid

Refernces

• 1、 -. "SULFINYLPHENYL OR SULFONIMIDOYLPHENYL BENZAZEPINES". Page/Page column 26; 27. . Retrieved 2017/04/11.
• 2、 Cummings, Matthew M.,Soederberg, Bjoern C. G.. "Reexamination of the bromination of 2-nitrobenzaldehyde with NBS or NaBr-NaIO4 in sulfuric acid". supporting information. p. 954 - 958. Retrieved 2014/03/21.