4-Chloro-3-fluorobenzyl alcohol

Base Information

• Chemical Name: 4-Chloro-3-fluorobenzyl alcohol
• CAS No.: 202925-10-8
• Molecular Formula: C7H6 Cl F O
• Molecular Weight: 160.575
• Hs Code.: 2906299090
• European Community (EC) Number: 642-733-4
• DSSTox Substance ID: DTXSID80378592
• Wikidata: Q72450666
• Mol file: 202925-10-8.mol

Synonyms:4-Chloro-3-fluorobenzyl alcohol;202925-10-8;(4-chloro-3-fluorophenyl)methanol;3-fluoro-4-chlorobenzyl alcohol;3-fluoro-4-chlorobenzylalcohol;Benzenemethanol,4-chloro-3-fluoro-;Benzenemethanol, 4-chloro-3-fluoro-;SCHEMBL2092848;DTXSID80378592;JEAFLVNESBTMPU-UHFFFAOYSA-N;(4-chloro-3-fluoro phenyl)methanol;CK2448;MFCD00143292;AKOS005257527;PS-8772;SY032304;4-chloro-3-fluorobenzyl alcohol, AldrichCPR;CS-0097353;FT-0676994;EN300-159799

Chemical Property of 4-Chloro-3-fluorobenzyl alcohol

Chemical Property:

• Vapor Pressure: 0.031mmHg at 25°C
• Boiling Point: 233℃
• Flash Point: 95℃
• PSA: 20.23000
• Density: 1.344
• LogP: 1.97140
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 160.0091207
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Chloro-3-fluorobenzylalcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1CO)F)Cl

Technology Process of 4-Chloro-3-fluorobenzyl alcohol

There total 2 articles about 4-Chloro-3-fluorobenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-3-fluorobenzoic acid (403-17-8) → (4-chloro-3-fluorophenyl)methanol (202925-10-8)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

Reference yield:

→ (4-chloro-3-fluorophenyl)methanol (202925-10-8)

Guidance literature:

Reference yield: 85.0%

(4-chloro-3-fluorophenyl)methanol (202925-10-8) → 4-(bromomethyl)-1-chloro-2-fluorobenzene (206362-80-3)

Guidance literature:

With bromine; triphenylphosphine; In ethanol; dichloromethane; at 0 ℃; for 0.5h;

upstream raw materials:

4-chloro-3-fluorobenzoic acid

Downstream raw materials:

4-((4-chloro-3-fluorobenzyl)oxy)-1-(2-ethyl-1-methyl-1H-benzimidazol-6-yl)pyridin-2(1H)-one

4-((4-chloro-3-fluorobenzyl)oxy)-1-(2-cyclopropyl-1-methyl-1H-benzimidazol-6-yl)pyridin-2(1H)-one

4-(bromomethyl)-1-chloro-2-fluorobenzene

Refernces

• 1、 -. "AMIDE COMPOUND AND METHOD OF CONTROLLING PLANT DISEASE WITH THE SAME". Page/Page column 108. . Retrieved 2010/02/14.