(R)-3-methyl-1-(2-(1-pieridinyl)phenyl)-butylamine

Base Information

• Chemical Name: (R)-3-methyl-1-(2-(1-pieridinyl)phenyl)-butylamine
• CAS No.: 219921-93-4
• Molecular Formula: C₁₆H₂₆N₂
• Molecular Weight: 246.396
• Mol file: 219921-93-4.mol

Synonyms:(R)-3-methyl-1-(2-(1-pieridinyl)phenyl)-butylamine

Chemical Property of (R)-3-methyl-1-(2-(1-pieridinyl)phenyl)-butylamine

Chemical Property:

Purity/Quality:

>95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-methyl-1-(2-(1-pieridinyl)phenyl)-butylamine

There total 31 articles about (R)-3-methyl-1-(2-(1-pieridinyl)phenyl)-butylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-<(S)-3-methyl-1-<2-(1-pieridinyl)phenyl>butyl>-N-<(S')-1-phenethyl>-amine (147770-01-2) → (R)-3-methyl-1-(2-(1-pieridinyl)phenyl)-butylamine (219921-93-4) + (1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butan-1-amine (147769-93-5)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In water; at 50 ℃; for 5h; under 3750.3 Torr; Yield given; Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jm9810349

Reference yield:

N-<(S)-3-methyl-1-<2-(1-piperidinyl)phenyl>butyl>-N-<(R')-1-phenethyl>-amine (219922-07-3) → (R)-3-methyl-1-(2-(1-pieridinyl)phenyl)-butylamine (219921-93-4) + (1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butan-1-amine (147769-93-5)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; at 50 ℃; for 5h; under 3750.3 Torr; Yield given; Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jm9810349

Reference yield:

N-<(R)-3-methyl-1-<2-(1-piperidinyl)phenyl>butyl>-N-<(R')-1-phenethyl>-amine (219921-97-8) → (R)-3-methyl-1-(2-(1-pieridinyl)phenyl)-butylamine (219921-93-4) + (1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butan-1-amine (147769-93-5)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; at 50 ℃; for 10h; under 3750.3 Torr; Yield given; Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jm9810349

upstream raw materials:

(S)-1-(2-piperidino-phenyl)-3-methyl-1-butylamine

N-acetyl-N-<(S)-3-methyl-1-(2-(1-piperidinyl)phenyl)-1-butyl>-amine

N-<(S)-3-methyl-1-<2-(1-piperidinyl)phenyl>butyl>-N-<(R')-1-phenethyl>-amine

N-<(S)-3-methyl-1-<2-(1-pieridinyl)phenyl>butyl>-N-<(S')-1-phenethyl>-amine

Downstream raw materials:

(R)-(-)-ethyl 2-ethoxy-4-<2-<<3-methyl-1-<2-(1-piperidinyl)phenyl>butyl>amino>-2-oxoethyl>-benzoate

S-PPA*3,5-DNTA

S-PPA*3,5-DNBA

rac-PPA*3,5-DNTA

Refernces

• 1、 Nagarajan, Periyandi,Rajendiran, Chinnapillai,Naidu,Dubey. "Studies on diastereofacial selectivity of a chiral tert-butanesulfinimines for the preparation of (S)-3-Methyl-1-(2-piperidin-1-yl-phenyl)butylamine for the synthesis of repaglinide". . p. 9345 - 9350. Retrieved 2013/11/19.
• 2、 Grell, Wolfgang,Hurnaus, Rudolf. "Repaglinide and related hypoglycemic benzoic acid derivatives". . p. 5219 - 5246. Retrieved 2007/10/03.