3-Cyano-6-isopropylchromone

Base Information

• Chemical Name: 3-Cyano-6-isopropylchromone
• CAS No.: 50743-32-3
• Molecular Formula: C13H11NO2
• Molecular Weight: 213.236
• Mol file: 50743-32-3.mol

Synonyms:6-Isopropyl-4-oxo-4H-1-benzopuran-3-carbonitrile;6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile;6-(Methylethyl)-4-oxochromene-3-carbonitrile;

Chemical Property of 3-Cyano-6-isopropylchromone

Chemical Property:

• Vapor Pressure: 0.000318mmHg at 25°C
• Melting Point: 117.0 to 121.0 °C
• Refractive Index: 1.578
• Boiling Point: 320.434 °C at 760 mmHg
• Flash Point: 139.331 °C
• PSA: 54.00000
• Density: 1.209 g/cm³
• LogP: 2.78808
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile is a useful research chemical.

Technology Process of 3-Cyano-6-isopropylchromone

There total 4 articles about 3-Cyano-6-isopropylchromone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

<(chlorosulfinyloxy)methylene>dimethylammonium chloride (25575-32-0) + 6-isopropyl-4-oxo-4H-chromene-3-carbaldehyde oxime → 6-isopropyl-4-oxo-4H-1-benzopyran-3-carbonitrile (50743-32-3)

Guidance literature:

In dichloromethane; at 0 - 20 ℃;

DOI:10.1515/HC.2004.10.4-5.279

Reference yield: 66.0%

3-formyl-6-isopropylchromone (49619-58-1) → 6-isopropyl-4-oxo-4H-1-benzopyran-3-carbonitrile (50743-32-3)

Guidance literature:

With hydroxylamine hydrochloride; sodium iodide; In acetonitrile; for 2h; Heating;

DOI:10.1080/00304940409355968

Reference yield: 65.0%

6-isopropyl-4-oxo-4H-1-benzopyran-3-carboxaldehyde 3-O-methyl oxime → 6-isopropyl-4-oxo-4H-1-benzopyran-3-carbonitrile (50743-32-3)

Guidance literature:

With 4 A molecular sieve; sulfuric acid; In benzene; Heating;

DOI:10.1021/jo991031j

upstream raw materials:

3-formyl-6-isopropylchromone

<(chlorosulfinyloxy)methylene>dimethylammonium chloride

Downstream raw materials:

2-amino-6-isopropyl-4-oxo-4H-1-benzopyran-3-carboxaldehyde

ethyl 2-amino-7-isopropyl-5-oxo-5H-<1>benzopyrano<2,3-b>pyridine-3-carboxylate

2-amino-7-isopropyl-5-oxo-5H-<1>benzopyrano<2,3-b>pyridine-3-carbonitrile

amlexanox

Refernces

• 1、 Jagath Reddy,Latha,Srinivasa Rao. "A mild and facile method for the synthesis of 3-cyano-chromones from oximes derived from 3-formylchromones using dimethylformamide-thionylchloride complex". . p. 279 - 282. Retrieved 2007/10/03.