3-Amino-L-alanine hydrochloride

Base Information

• Chemical Name: 3-Amino-L-alanine hydrochloride
• CAS No.: 1482-97-9
• Molecular Formula: C3H8N2O2^.HCl
• Molecular Weight: 140.57
• Hs Code.: 29224999
• European Community (EC) Number: 625-088-3
• UNII: 68H9573890
• Wikidata: Q27264255
• Mol file: 1482-97-9.mol

Synonyms:1482-97-9;3-Amino-L-alanine hydrochloride;H-Dap-OH.HCl;(S)-2,3-diaminopropanoic acid hydrochloride;L-2,3-Diaminopropionic acid hydrochloride;L(+)-2,3-Diaminopropionic acid hydrochloride;L-(+)-2,3-Diaminopropionic acid hydrochloride;(2S)-2,3-diaminopropanoic acid hydrochloride;2,3-Diaminopropionic acid hydrochloride, (+)-;3-Amino-L-alanine, HCl;L-Alanine, 3-amino-, hydrochloride (1:1);(2S)-2,3-diaminopropanoic acid;hydrochloride;(S)-2,3-Diaminopropionic acid monohydrochloride;2,3-Diaminopropionic acid L-form hydrochloride [MI];L-3-Aminoalanine Hydrochloride;2,3-Diaminopropionic acid hydrochloride;68H9573890;L-Alanine, 3-amino-, monohydrochloride;H-Dapa-OH.HCl;(S)-(+)-2,3-Diaminopropionic Acid Hydrochloride;Alanine, 3-amino-, monohydrochloride;MFCD00065497;UNII-68H9573890;3-Amino-l-alanine HCl;H-DL-Dap-OH. HCl;L-alpha,beta-Diaminopropionic acid hydrochloride;SCHEMBL5548567;SKWCZPYWFRTSDD-DKWTVANSSA-N;AKOS015847929;AC-5654;CS-W014389;HY-W013673;3-Amino-L-alanine hydrochloride (1:1);BP-11084;DS-10772;PD121804;(+)-2,3-diaminopropionic acid hydrochloride;3-Amino-L-Alanine hydrochloride, AldrichCPR;AM20080367;D1377;M03240;D-(-)-2, 3-Diaminopropionic acid hydrochloride;J-520200;J-800394;Q-101549;L-2,3-Diaminopropionic acid hydrochloride, >=97.0%;Q27264255;L-.ALPHA.,.BETA.-DIAMINOPROPIONIC ACID HYDROCHLORIDE

Chemical Property of 3-Amino-L-alanine hydrochloride

Chemical Property:

• Appearance/Colour: white crystalline powder
• Melting Point: 231-233 °C (dec.)
• Refractive Index: 24 ° (C=2, 1mol/L HCl)
• Boiling Point: 329.9 °C at 760 mmHg
• Flash Point: 153.3 °C
• PSA: 89.34000
• LogP: 0.55960
• Storage Temp.: 2-8°C
• Sensitive.: Hygroscopic
• Solubility.: Aqueous Acid (Slightly), Water (Slightly)
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 140.0352552
• Heavy Atom Count: 8
• Complexity: 73.3

Purity/Quality:

99% ^*data from raw suppliers

H-L-Dap-OH*HCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

Useful:

• Canonical SMILES: C(C(C(=O)O)N)N.Cl
• Isomeric SMILES: C([C@@H](C(=O)O)N)N.Cl
• Uses: (2S)-2,3-Diaminopropanoic Acid Hydrochloride is a non-proteinogenic amino acid that can be used in the synthesis of peptides containing non-proteinogenic amino acids.

Technology Process of 3-Amino-L-alanine hydrochloride

There total 20 articles about 3-Amino-L-alanine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Boc-Dap(NH2)-CONH2 (75452-33-4) → (S)-2,3-diaminopropanoic acid hydrochloride (1482-97-9)

Guidance literature:

With hydrogenchloride; for 4h; Heating;

DOI:10.1021/jo00313a016

Reference yield: 93.0%

Fmoc-Dap-OH → (2R)-2,3-diaminopropanoic acid monohydrochloride (1482-97-9,6018-55-9,6018-56-0,19777-68-5,19777-69-6,28843-13-2,54897-59-5,69531-11-9,125767-61-5)

Guidance literature:

With diethylamine; In ethanol; at 27 ℃; Temperature; Concentration;

Reference yield: 93.0%

(S)-3-amino-2-(((benzyloxy)carbonyl)amino)propanoic acid (35761-26-3) → (S)-2,3-diaminopropanoic acid hydrochloride (1482-97-9)

Guidance literature:

With hydrogenchloride; hydrogen; palladium; 1.) AcOH, H₂O, 3 h;

DOI:10.1055/s-1981-29407

upstream raw materials:

(S)-3-amino-2-tert-butoxycarbonylaminopropionic acid

(2S)-3-amino-2-<(tert-butoxycarbonyl)amino>propionamide hydrochloride

Boc-Dap(NH₂)-CONH₂

(1'S,4S)-1-(1'-Phenyleth-1'-yl)-4-methoxycarbonylimidazolidin-2-one

Downstream raw materials:

b-oxalylamino-L-alanine

α-N-oxalyl-L-α,β-diaminopropionic acid

DPAB-L-DPA (trans)

N^α,N^β-bis(t-butoxycarbonyl)-L-α,β-diaminopropionic acid

Refernces

• 1、 Mar?eková, Michaela,Ger?a, Peter,?oral, Michal,Moncol, Ján,Berke?, Du?an,Kolarovi?, Andrej,Jakubec, Pavol. "Crystallization Does It All: An Alternative Strategy for Stereoselective Aza-Henry Reaction". supporting information. p. 4580 - 4584. Retrieved 2019/06/17.
• 2、 -. "Preparation method and application of D-dencichine". Paragraph 0081; 0082. . Retrieved 2016/10/17.