2-Amino-4'-methylacetophenone

Base Information

• Chemical Name: 2-Amino-4'-methylacetophenone
• CAS No.: 69872-37-3
• Molecular Formula: C9H11 N O
• Molecular Weight: 149.192
• Hs Code.: 2922399090
• Mol file: 69872-37-3.mol

Synonyms:Acetophenone,2-amino-4'-methyl- (7CI); 2-Amino-4'-methylacetophenone

Chemical Property of 2-Amino-4'-methylacetophenone

Chemical Property:

• Boiling Point: 272.6±23.0 °C(Predicted)
• PKA: 7.10±0.29(Predicted)
• PSA: 43.09000
• Density: 1.058±0.06 g/cm3(Predicted)
• LogP: 1.83670

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-1-(p-tolyl)ethanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-4'-methylacetophenone

There total 5 articles about 2-Amino-4'-methylacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-(bromoacetyl)toluene (619-41-0) → 4-(α-aminoacetyl)toluene (69872-37-3)

Guidance literature:

4-(bromoacetyl)toluene; With hexamethylenetetramine; In chloroform; at 60 ℃; for 5h;

With hydrogenchloride; In ethanol; water; at 85 ℃; for 14h;

Reference yield: 85.0%

2-azido-1-(4-methylphenyl)ethan-1-one (6595-30-8) → 4-(α-aminoacetyl)toluene (69872-37-3)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; at 20 ℃; for 5h; under 1810.07 - 2068.65 Torr;

DOI:10.1016/j.bmcl.2011.08.099

Reference yield:

para-methylacetophenone (122-00-9) → 4-(α-aminoacetyl)toluene (69872-37-3)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen bromide; bromine / methanol / 3 h / 20 °C

2: sodium azide / N,N-dimethyl-formamide / 4 h / 20 °C

3: palladium 10% on activated carbon; hydrogenchloride; hydrogen / methanol / 20 °C

With hydrogenchloride; sodium azide; palladium 10% on activated carbon; hydrogen bromide; hydrogen; bromine; In methanol; N,N-dimethyl-formamide;

DOI:10.3987/COM-12-12565

upstream raw materials:

2-azido-1-(4-methylphenyl)ethan-1-one

para-methylacetophenone

4-(bromoacetyl)toluene

Downstream raw materials:

N-(2-oxo-2-p-tolylethyl)nicotinamide

(E)-3-(2-hydroxyphenyl)-N-(2-oxo-2-p-tolylethyl)acrylamide

2-(3,4-dimethoxyphenyl)-N-(2-oxo-2-p-tolylethyl)acetamide

N-(2-oxo-2-p-tolylethyl)-2-(pyridin-3-yl)acetamide

Refernces

• 1、 -. "Pyrazole-pyrimido imidazole compound as well as preparation method and application thereof". Paragraph 0061-0063. . Retrieved 2020/04/22.
• 2、 Micheli, Fabrizio,Cremonesi, Susanna,Semeraro, Teresa,Tarsi, Luca,Tomelleri, Silvia,Cavanni, Paolo,Oliosi, Beatrice,Perdon, Elisabetta,Sava, Anna,Zonzini, Laura,Feriani, Aldo,Braggio, Simone,Heidbreder, Christian. "Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists". . p. 1329 - 1332. Retrieved 2016/02/23.