3-Aminopiperidine dihydrochloride

Base Information

• Chemical Name: 3-Aminopiperidine dihydrochloride
• CAS No.: 138060-07-8
• Molecular Formula: C₅H₁₂N₂*2ClH
• Molecular Weight: 173.086
• Hs Code.: 2933399090
• European Community (EC) Number: 630-778-2
• DSSTox Substance ID: DTXSID40583504
• Mol file: 138060-07-8.mol

Synonyms:138060-07-8;3-Aminopiperidine dihydrochloride;piperidin-3-amine dihydrochloride;3-Aminopiperidine 2HCl;(S)-3-Aminopiperidine dihydrochloride;piperidin-3-amine;dihydrochloride;3-Aminopiperidine DiHCl;MFCD00012773;3-piperidinamine dihydrochloride;(R)-3-Amino-Piperidine dihydrochloride;3-Piperidinamine, dihydrochloride;3-Piperidinamine, hydrochloride (1:2);MFCD03427036;MFCD06799458;3-AMINOPIPERIDINE HCL;SCHEMBL306091;piperidin-3-aminedihydrochloride;DTXSID40583504;GGPNYXIOFZLNKW-UHFFFAOYSA-N;BCP08366;3-Amino-Piperidine Di-Hydrochloride;AC-876;AKOS015894260;AB15031;AB29962;AM81346;CS-W002078;DS-0819;SB42934;SB44203;3-Aminopiperidine dihydrochloride, 97%;racemic 3-aminopiperidine dihydrochloride;SY008763;SY009305;SY020460;TS-02363;Piperidin-3-amine--hydrogen chloride (1/2);EN300-136385;A807330;(+/-)-2-ISOPROPENYL-5-METHYL-4-HEXEN-1-YLACETATE;2-TERT-BUTOXYCARBONYLAMINO-CYCLOPENTANECARBOXYLICACID

Chemical Property of 3-Aminopiperidine dihydrochloride

Chemical Property:

• Appearance/Colour: Off-white to beige powder
• Vapor Pressure: 0.028mmHg at 25°C
• Melting Point: 230 ºC (dec.)
• Boiling Point: 241.9°C at 760 mmHg
• Flash Point: 100.1°C
• PSA: 38.05000
• LogP: 2.33020
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Hygroscopic
• Solubility.: Methanol (Sparingly), Water (Slightly)
• Water Solubility.: Partly miscible in water.
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 172.0534038
• Heavy Atom Count: 9
• Complexity: 54

Purity/Quality:

99.9% ^*data from raw suppliers

3-Aminopiperidine dihydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(CNC1)N.Cl.Cl
• Uses: Reactant for N-arylation of heterocyclic diamines Reactant for synthesis of substituted quinolones with reduced phototoxic risk It is used as a reactant for N-arylation of heterocyclic diamines and for synthesis of substituted quinolones with reduced phototoxic risk. Reactant for N-arylation of heterocyclic diaminesReactant for synthesis of substituted quinolones with reduced phototoxic risk

Technology Process of 3-Aminopiperidine dihydrochloride

There total 14 articles about 3-Aminopiperidine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.5%

nipecotamide (4138-26-5,168749-30-2) → 3-amino-piperidine dihydrochloride (127294-75-1,138060-07-8,150395-91-8,334618-23-4)

Guidance literature:

nipecotamide; With tetrafluoroboric acid; 1-Fluoronaphthalene; dihydrogen peroxide;

With hydrogenchloride; In ethanol; water; for 0.5h;

Reference yield: 92.0%

t-butyl piperidin-3-ylcarbamate (184637-48-7,172603-05-3) → 3-amino-piperidine dihydrochloride (127294-75-1,138060-07-8,150395-91-8,334618-23-4)

Guidance literature:

With hydrogenchloride; In ethanol; ethyl acetate; at 50 ℃; for 5h;

Reference yield: 84.0%

piperidine-3-carboxylic acid hydrazide dihydrochloride → 3-amino-piperidine dihydrochloride (127294-75-1,138060-07-8,150395-91-8,334618-23-4)

Guidance literature:

With acetic acid; isopentyl nitrite; In water; at -15 ℃; for 2.16667h; Solvent; Reflux;

upstream raw materials:

pyridin-3-ylamine

N-acetyl-3-aminopyridine acetate

N-acetyl-3-aminopiperidine acetate

nipecotamide

Downstream raw materials:

3-amino-1-phenylpiperidine

3-(phenylamino)piperidine

(2-ethyl-phenyl)-piperidin-3-yl-amine

3-amino-1-(2-ethylphenyl)piperidine

Refernces

• 1、 -. "Intermediate argues a row sandbank R-3-amino piperidine dihydrochloride preparation method". Paragraph 0018; 0019. . Retrieved 2018/02/04.
• 2、 Miyamoto, Kazunori,Sakai, Yuuta,Goda, Shunsuke,Ochiai, Masahito. "A catalytic version of hypervalent aryl-λ3-iodane-induced Hofmann rearrangement of primary carboxamides: Iodobenzene as an organocatalyst and m-chloroperbenzoic acid as a terminal oxidant". supporting information; experimental part. p. 982 - 984. Retrieved 2012/02/04.