2-[(2-Aminothiazol-4-yl)carboxymethyleneaminooxy]-2-methylpropionic acid

Base Information

• Chemical Name: 2-[(2-Aminothiazol-4-yl)carboxymethyleneaminooxy]-2-methylpropionic acid
• CAS No.: 80542-76-3
• Molecular Formula: C22H21 N3 O5 S
• Molecular Weight: 439.492
• Hs Code.: 2934100090
• Mol file: 80542-76-3.mol

Synonyms:2-(2-amino-4-thiazolyl)-(Z)-2-(methoxycarbonylmethoxyimino)acetic acid;(Z)-(2-Amino-4-thiazolyl)[[2-(diphenylmethoxy)-1,1-dimethyl-2-oxoethoxy]imino]acetic acid;(Z)-2-(2-aminothiazol-4-yl)-(methoxycarbonyl)methoxyimino acetic acid;2-(2-amino-4-thiazolyl)-(Z)-2-[(1-diphenylmethoxycarbonyl-1-methylethoxy)imino]acetic acid;(Z)-2-(2-Aminothiazol-4-yl)-2-((2-methoxy-2-oxoethoxy)imino)acetic acid;(z)-2-(methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid;(Z)-2-(tert-Methoxycarbonyl Methoxyimino)-2-(2-Aminothiazol-4-yl) acetic acid;2-(2-aminothiazol-4-yl)-2-syn-(2-diphenylmethoxy-2-oxo-1,1-dimethylethoxyimino)acetic acid;

Chemical Property of 2-[(2-Aminothiazol-4-yl)carboxymethyleneaminooxy]-2-methylpropionic acid

Chemical Property:

• Boiling Point: 627.2±65.0 °C(Predicted)
• PKA: 2.55±0.10(Predicted)
• PSA: 163.34000
• Density: 1.33±0.1 g/cm3(Predicted)
• LogP: 0.97500

Purity/Quality:

99% ^*data from raw suppliers

2-[(2-Amino-thiazol-4-yl)-carboxy-methyleneaminooxy]-2-methyl-propionicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(2-Aminothiazol-4-yl)carboxymethyleneaminooxy]-2-methylpropionic acid

There total 2 articles about 2-[(2-Aminothiazol-4-yl)carboxymethyleneaminooxy]-2-methylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-oxo-2-(2-aminothiazol-4-yl)acetic acid (73150-67-1) + O-(1-diphenylmethoxycarbonyl-1-methylethyl)hydroxylamine (77497-44-0) → (Z)-2-Amino-α-[[2-(diphenylmethoxy)-1,1-dimethyl-2-oxoethoxy]-imino]-4-thiazoleacetic acid (80542-76-3,77497-47-3)

Guidance literature:

In ethanol;

Reference yield:

→ (Z)-2-Amino-α-[[2-(diphenylmethoxy)-1,1-dimethyl-2-oxoethoxy]-imino]-4-thiazoleacetic acid (80542-76-3,77497-47-3)

Guidance literature:

Reference yield: 84.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + (Z)-2-Amino-α-[[2-(diphenylmethoxy)-1,1-dimethyl-2-oxoethoxy]-imino]-4-thiazoleacetic acid (80542-76-3,77497-47-3) → 2-{[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethylidene]amino]oxy}-2-methylpropionic acid benzhydryl ester

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 30 ℃; for 2h;

DOI:10.1021/op025572d

upstream raw materials:

2-oxo-2-(2-aminothiazol-4-yl)acetic acid

O-(1-diphenylmethoxycarbonyl-1-methylethyl)hydroxylamine

Downstream raw materials:

3-<<(2-amino-4-thiazolyl)-<<1-(diphenylmethoxycarbonyl)-1-methyl ethoxy>-imino>-acetyl>-amino>-4-methyl-2-oxoazetidi-ne-1-sulfonic acid

2-(2-amino-4-thiazolyl)-(Z)-2-[(1-diphenylmethoxycarbonyl-1-methylethoxy)imino]thioacetic acid-S-benzothiazol-2-ylester

azthreonam

(Z)-2-[[[1-(2-amino-4-thiazolyl)-2-(3-oxido-1H-benzotriazol-1-yl)-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid diphenylmethyl ester methanesulfonate (1:1) salt

Refernces