(R)-2-Benzylsuccinic acid

Base Information

• Chemical Name: (R)-2-Benzylsuccinic acid
• CAS No.: 21307-97-1
• Molecular Formula: C11H12O4
• Molecular Weight: 208.214
• Hs Code.: 2917399090
• Mol file: 21307-97-1.mol

Synonyms:Butanedioicacid, (phenylmethyl)-, (2R)- (9CI);Butanedioic acid, (phenylmethyl)-, (R)-;Succinic acid, benzyl-, D-(+)- (8CI);(+)-a-Benzylsuccinic acid;(R)-2-(Phenylmethyl)butanedioicacid;(R)-2-Benzylsuccinic acid;(R)-Benzylsuccinic acid;2(R)-Benzyl-3-carboxypropionic acid;D-Benzylsuccinic acid;

Chemical Property of (R)-2-Benzylsuccinic acid

Chemical Property:

• Vapor Pressure: 6.23E-05mmHg at 25°C
• Refractive Index: 1.567
• Boiling Point: 331.4 °C at 760 mmHg
• Flash Point: 168.4 °C
• PSA: 74.60000
• Density: 1.290g/cm³
• LogP: 1.40460

Purity/Quality:

99%, ^*data from raw suppliers

(R)-2-Benzylsuccinicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-Benzylsuccinic acid

There total 26 articles about (R)-2-Benzylsuccinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2R)-3-tert-Butyloxycarbonyl-2-phenylmethylpropionic Acid (122225-33-6) → (R)-2-benzylsuccinic acid (21307-97-1,884-33-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 12h;

DOI:10.1039/a908747h

Reference yield: 94.0%

(Z)-2-benzylidenesuccinic acid (65756-81-2) → (2S)-benzylsuccinic acid (3972-36-9,884-33-3) + (R)-2-benzylsuccinic acid (21307-97-1,884-33-3)

Guidance literature:

With hydrogen; triethylamine; Ru₂Cl₄((R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl)2; In tetrahydrofuran; toluene; at 35 ℃; for 24h; under 2206.5 Torr; Title compound not separated from byproducts; op = 90percent, var. cat. RuHCl*2<(+)-BINAP>;

DOI:10.1016/S0040-4039(00)96006-4

Reference yield: 72.0%

(R)-2-benzyl-3-formylpropanoic acid dicyclohexylamine salt → (R)-2-benzylsuccinic acid (21307-97-1,884-33-3)

Guidance literature:

With sodium chlorite; sodium dihydrogen phosphate; 2-methyl-but-2-ene; In tert-butyl alcohol; at 20 ℃; for 0.5h;

DOI:10.1016/S0957-4166(99)00421-8

upstream raw materials:

2-benzylsuccinic acid

(R)-2-benzyl-4-ethoxy-4-oxobutanoic acid

trans-phenylitaconic acid

(Z)-2-benzylidenesuccinic acid

Downstream raw materials:

dimethyl (R)-(+)-benzylsuccinate

(R)-3-benzyl-4-((3aR,7aS)-1H-isoindol-2(3H,3aH,4H,5H,6H,7H,7aH)-yl)-4-oxobutanoic acid

(R)-4-oxo-1,2,3,4-tetrahydronaphthalen-2-ylmetyl 4-methylbenzenesulfonate

(R)-(-)-3-hydroxymethyl-1,2,3,4-tetrahydronaphthalen-1-one

Refernces

• 1、 Umasankara Sastry,Nageswara Rao,Appi Reddy,Gandhi. "Identification, synthesis and characterization of impurities of (S)-Mitiglinide calcium dihydrate". . p. 2417 - 2421. Retrieved 2014/06/09.
• 2、 Boaz, Neil W.,Mackenzie, Elaine B.,Debenham, Sheryl D.,Large, Shannon E.,Ponasik Jr., James A.. "Synthesis and application of phosphinoferrocenylaminophosphine ligands for asymmetric catalysis". . p. 1872 - 1880. Retrieved 2007/10/03.