1,3-Diphenyl-propin-1-on-oxim

Base Information

• Chemical Name: 1,3-Diphenyl-propin-1-on-oxim
• CAS No.: 28164-35-4
• Molecular Formula: C₁₅H₁₁NO
• Molecular Weight: 221.258
• Mol file: 28164-35-4.mol

Synonyms:1,3-Diphenyl-propin-1-on-oxim

Chemical Property of 1,3-Diphenyl-propin-1-on-oxim

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-Diphenyl-propin-1-on-oxim

There total 6 articles about 1,3-Diphenyl-propin-1-on-oxim which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

1,3-diphenyl-2-propynone (7338-94-5) → 3,5-diphehylisoxazole (2039-49-8) + 1,3-diphenylprop-2-yn-1-one oxime (28164-35-4)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In methanol; water; at 20 ℃; for 5h;

DOI:10.1246/bcsj.80.567

Reference yield:

1,3-diphenyl-2-propynone (7338-94-5) → 1,3-diphenylprop-2-yn-1-one oxime (28164-35-4)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; sodium sulfate; In methanol; at 20 ℃;

DOI:10.1002/adsc.201300005

Reference yield:

1,3-diphenyl-2-propynone (7338-94-5) → (E)-1,3-diphenylpropyl-2-yn-1-one oxime + 1,3-Diphenyl-propin-1-on-oxim (28164-35-4)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydrogencarbonate; In methanol;

DOI:10.1055/s-0029-1219342

upstream raw materials:

phenylacetylene

benzohydroximoyl chloride

1,3-diphenyl-2-propynone

benzonitrile oxide

Downstream raw materials:

3,5-diphehylisoxazole

3,5-diphenyl-4-(2-propen-1-yl)isoxazole

4-(2-methyl-2-propen-1-yl)-3,5-diphenylisoxazole

Refernces

• 1、 Kung, Karen Ka-Yan,Lo, Vanessa Kar-Yan,Ko, Hok-Ming,Li, Gai-Li,Chan, Pui-Ying,Leung, King-Chi,Zhou, Zhongyuan,Wang, Ming-Zhong,Che, Chi-Ming,Wong, Man-Kin. "Cyclometallated gold(III) complexes as effective catalysts for synthesis of propargylic amines, chiral allenes and isoxazoles". supporting information. p. 2055 - 2070. Retrieved 2013/08/23.
• 2、 Shimada, Kazuaki,Moro-oka, Akiko,Maruyama, Akiko,Fujisawa, Hiroyuki,Saito, Toshio,Kawamura, Ryo,Kogawa, Hisashi,Sakuraba, Maiko,Takata, Yukichi,Aoyagi, Shigenobu,Takikawa, Yuji,Kabuto, Chizuko. "Synthesis of isochalcogenazole rings by treating β-(N,N- dimethylcarbamoylchalcogenenyl)alkenyl ketones with hydroxylamine-O-sulfonic acid". . p. 567 - 577. Retrieved 2008/02/11.