2-Bromobenzenesulphonyl chloride

Base Information

• Chemical Name: 2-Bromobenzenesulphonyl chloride
• CAS No.: 2905-25-1
• Molecular Formula: C6H4BrClO2S
• Molecular Weight: 255.52
• Hs Code.: 29049090
• Mol file: 2905-25-1.mol

Synonyms:Benzenesulfonylchloride, o-bromo- (8CI);2-Bromobenzenesulfonyl chloride;2-Bromophenylsulfonyl chloride;o-Bromobenzenesulfonyl chloride;

Chemical Property of 2-Bromobenzenesulphonyl chloride

Chemical Property:

• Appearance/Colour: slightly yellow crystalline powder
• Vapor Pressure: 0.000974mmHg at 25°C
• Melting Point: 49-52 °C(lit.)
• Refractive Index: 1.591
• Boiling Point: 312.4 °C at 760 mmHg
• Flash Point: 142.7 °C
• PSA: 42.52000
• Density: 1.795 g/cm³
• LogP: 3.45740
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Moisture Sensitive

Purity/Quality:

99% ^*data from raw suppliers

2-Bromobenzenesulfonyl Chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Bromobenzenesulfonyl Chloride 2-Bromobenzenesulfonyl chloride may be used in the following:Preparation of 2-bromobenzenesulfonic acid phenyl ester.For the sufonylation during the synthesis of 2-bromobenzenesulfonamide.Synthesis of chiral 2-(p-toluenesulfinyl)benzenesulfonamide.

Technology Process of 2-Bromobenzenesulphonyl chloride

There total 10 articles about 2-Bromobenzenesulphonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-bromo-2-<(methoxymethyl)thio>benzene (146335-10-6) → o-bromobenzenesulfonyl chloride (2905-25-1)

Guidance literature:

With water; chlorine; In dichloromethane; at 5 - 10 ℃; for 1h;

DOI:10.1055/s-1992-26333

Reference yield: 90.0%

2-bromoaniline (615-36-1) → o-bromobenzenesulfonyl chloride (2905-25-1)

Guidance literature:

2-bromoaniline; With tris(bipyridine)ruthenium(II) dichloride hexahydrate; isopentyl nitrite; In acetonitrile; at 20 ℃; for 0.0833333h; Sealed tube;

With thionyl chloride; In water; acetonitrile; at 20 ℃; for 20h; Irradiation;

DOI:10.1002/cssc.201601293

Reference yield: 84.0%

2-bromobenzenediazonium tetrafluoroborate (10448-07-4) → o-bromobenzenesulfonyl chloride (2905-25-1)

Guidance literature:

With thionyl chloride; tris(bipyridine)ruthenium(II) dichloride hexahydrate; In water; acetonitrile; at 20 ℃; for 20h; Sealed tube; Irradiation;

DOI:10.1002/cssc.201601293

upstream raw materials:

1-bromo-2-<(methoxymethyl)thio>benzene

2-bromoaniline

(2-bromophenyl)boronic acid

bromobenzene

Downstream raw materials:

N-(3,4-Dimethyl-5-isoxazolyl)-2-bromo-benzenesulfonamide

4-[(2-bromo-benzenesulfonylamino)-methyl]-cyclohexanecarboxylic acid

(Z)-7-[(1S,2R,3R,4R)-3-(2-Bromo-benzenesulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid methyl ester

N-(4,5-dimethyl-3-isoxazolyl)-2-bromobenzenesulfonamide

Refernces

• 1、 Wang, Wei,Bao, Zhi-Peng,Qi, Xinxin,Wu, Xiao-Feng. "Nickel-Catalyzed One-Pot Carbonylative Synthesis of 2-Mono- And 2,3-Disubstituted Thiochromenones from 2-Bromobenzenesulfonyl Chlorides and Alkynes". supporting information. p. 6589 - 6593. Retrieved 2021/08/30.
• 2、 Arshad, Muhammad Nadeem,Siddiqui, Waseeq Ahmad,Khan, Islam Ullah,Asiri, Abdullah M.. "Ligand free Pd catalyzed cyclization-influence of steric hindrance". . p. 2697 - 2700. Retrieved 2015/01/30.