3-(4-methoxyphenyl)-2H-chromene

Base Information

• Chemical Name: 3-(4-methoxyphenyl)-2H-chromene
• CAS No.: 145917-96-0
• Molecular Formula: C₁₆H₁₄O₂
• Molecular Weight: 238.286
• Mol file: 145917-96-0.mol

Synonyms:3-(4-methoxyphenyl)-2H-chromene

Chemical Property of 3-(4-methoxyphenyl)-2H-chromene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3-(4-methoxyphenyl)-2H-chromene

There total 11 articles about 3-(4-methoxyphenyl)-2H-chromene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

{2-[2-(4-methoxyphenyl)ethynyl]phenyl}methanol (405198-79-0) → 3-(4-methoxyphenyl)-2H-chromene (145917-96-0)

Guidance literature:

With dipotassium peroxodisulfate; copper(II) bis(trifluoromethanesulfonate); In acetonitrile; at 120 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.7b00937

Reference yield:

C34H30O3P(1+)*Br(1-) → 3-(4-methoxyphenyl)-2H-chromene (145917-96-0)

Guidance literature:

With sodium ethanolate; In ethanol; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b02341

Reference yield:

(3S,4S)-3-(4-Methoxy-phenyl)-chroman-4-ol → 3-(4-methoxyphenyl)-2H-chromene (145917-96-0) + (3R,4R)-4-Azido-3-(4-methoxy-phenyl)-chroman

Guidance literature:

With diphenyl phosphoryl azide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at -78 - 20 ℃; Title compound not separated from byproducts;

DOI:10.1021/jm950833d

upstream raw materials:

4-methoxyphenylboronic acid

2H-chromen-3-yl trifluoromethanesulfonate

salicylonitrile

3-(4-methoxyphenyl)chroman-4-one

Refernces

• 1、 Xia, Jingzhao,Nie, Yu,Yang, Guoqiang,Liu, Yangang,Zhang, Wanbin. "Iridium-Catalyzed Asymmetric Hydrogenation of 2H-Chromenes: A Highly Enantioselective Approach to Isoflavan Derivatives". . p. 4884 - 4887. Retrieved 2017/09/23.
• 2、 Vaccaro, Wayne,Amore, Cindy,Berger, Joel,Burrier, Robert,Clader, John,Davis, Harry,Domalski, Martin,Fevig, Tom,Salisbury, Brian,Sher, Rosy. "Inhibitors of acyl CoA:cholesterol acyltransferase". . p. 1704 - 1719. Retrieved 2007/10/03.