1-Cbz-4-Aminomethylpiperidine

Base Information

• Chemical Name: 1-Cbz-4-Aminomethylpiperidine
• CAS No.: 157023-34-2
• Molecular Formula: C14H20N2O2
• Molecular Weight: 248.325
• Hs Code.: 2933399090
• Mol file: 157023-34-2.mol

Synonyms:Benzyl 4-(aminomethyl)piperidine-1-carboxylate;4-(Aminomethyl)piperidine-1-carboxylicacid benzyl ester;

Chemical Property of 1-Cbz-4-Aminomethylpiperidine

Chemical Property:

• Boiling Point: 385.709 °C at 760 mmHg
• PKA: 10.13±0.29(Predicted)
• Flash Point: 187.07 °C
• PSA: 55.56000
• Density: 1.126 g/cm³
• LogP: 2.63210

Purity/Quality:

98%,99%, ^*data from raw suppliers

Benzyl4-(Aminomethyl)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: R36/37/38:
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Cbz-4-Aminomethylpiperidine

There total 10 articles about 1-Cbz-4-Aminomethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(1-benzyloxycarbonylpiperidin-4-ylmethyl)phthalimide (396072-76-7) → 4-aminomethyl-piperidine-1-carboxylic acid benzyl ester (157023-34-2)

Guidance literature:

With hydrazine hydrate; In ethanol;

DOI:10.1016/S0960-894X(01)00170-6

Reference yield:

N-(Benzyloxycarbonyloxy)succinimide (13139-17-8) + 4-Aminomethylpiperidine (7144-05-0) → 4-aminomethyl-piperidine-1-carboxylic acid benzyl ester (157023-34-2)

Guidance literature:

With hydrogenchloride; benzaldehyde; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

dibenzyl dicarbonate (31139-36-3) + 4-Aminomethylpiperidine (7144-05-0) → 4-aminomethyl-piperidine-1-carboxylic acid benzyl ester (157023-34-2)

Guidance literature:

With benzaldehyde; In toluene;

upstream raw materials:

N-(1-benzyloxycarbonylpiperidin-4-ylmethyl)phthalimide

4-Aminomethylpiperidine

N-hexahydro-4-pyridinylmethyl-N-phenylmethylidenamine

4-(phthalimidomethyl)piperidine

Downstream raw materials:

4-[(4-cyano-benzenesulfonylamino)-methyl]-piperidine-1-carboxylic acid benzyl ester

4-{[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butylamino]-methyl}-piperidine-1-carboxylic acid benzyl ester

1-benzyloxycarbonyl-4-[N-tert-butoxylcarbonyl-N-(4-oxobutyl)amino]methylpiperidine

4-{[tert-butoxycarbonyl-(4-hydroxy-butyl)-amino]-methyl}-piperidine-1-carboxylic acid benzyl ester

Refernces

• 1、 Yoneda, Yoshiyuki,Mimura, Tetuya,Kawagoe, Keiichi,Yasukouchi, Takanori,Tatematu, Toshiaki,Ito, Masayuki,Saito, Masaki,Sugimura, Masunobu,Kito, Fusako,Kawajiri, Shinichi. "Discovery of diaminobutane derivatives as Ca(2+)-permeable AMPA receptor antagonists.". . p. 1347 - 1359. Retrieved 2007/10/03.
• 2、 -. "N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists". . . Retrieved 2019/08/08.