2-Chloro-5-fluoro-3-methylpyridine

Base Information

• Chemical Name: 2-Chloro-5-fluoro-3-methylpyridine
• CAS No.: 38186-84-4
• Molecular Formula: C₆H₅ClFN
• Molecular Weight: 145.564
• Hs Code.: 2933399090
• European Community (EC) Number: 692-489-8
• DSSTox Substance ID: DTXSID70511471
• Wikidata: Q72450913
• Mol file: 38186-84-4.mol

Synonyms:2-Chloro-5-fluoro-3-methylpyridine;38186-84-4;2-Chloro-5-fluoro-3-picoline;MFCD04972725;2-Chloro-5-fluoro-3-methyl-pyridine;PYRIDINE, 2-CHLORO-5-FLUORO-3-METHYL-;SCHEMBL1853177;DTXSID70511471;FMPYGEFGXUAAKG-UHFFFAOYSA-N;AMY28408;AKOS005063608;AB21234;AC-1510;CS-W003216;PS-8951;SY023651;A6482;C3144;FT-0650044;EN300-88327

Chemical Property of 2-Chloro-5-fluoro-3-methylpyridine

Chemical Property:

• Vapor Pressure: 1.369mmHg at 25°C
• Melting Point: 41.0 to 45.0 °C
• Refractive Index: 1.504
• Boiling Point: 177.928 °C at 760 mmHg
• PKA: -1.59±0.10(Predicted)
• Flash Point: 61.409 °C
• PSA: 12.89000
• Density: 1.265 g/cm³
• LogP: 2.18250
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 145.0094550
• Heavy Atom Count: 9
• Complexity: 99.1

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-5-fluoro-3-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CN=C1Cl)F

Technology Process of 2-Chloro-5-fluoro-3-methylpyridine

There total 4 articles about 2-Chloro-5-fluoro-3-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-chloro-5-fluoropyridin-3-yl)methyl methanesulfonate (1097264-82-8) → 2-chloro-5-fluoro-3-methylpyridine (38186-84-4)

Guidance literature:

(2-chloro-5-fluoropyridin-3-yl)methyl methanesulfonate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

With hydrogenchloride; water; In tetrahydrofuran; for 0.5h;

Reference yield:

6-chloro-5-methylpyridin-3-amine (38186-82-2) → 2-chloro-5-fluoro-3-methylpyridine (38186-84-4)

Guidance literature:

With hexafluorophosphoric acid; diazotisation;

DOI:10.1016/0223-5234(89)90006-8

Reference yield:

6-chloro-5-methylpyridin-3-amine (38186-82-2) → 2-chloro-5-hydroxy-3-methylpyridine (54232-03-0) + 2-chloro-5-fluoro-3-methylpyridine (38186-84-4)

Guidance literature:

With hydrogenchloride; hexafluorophosphoric acid; sodium nitrite; Yield given. Multistep reaction. Yields of byproduct given;

upstream raw materials:

6-chloro-5-methylpyridin-3-amine

(2-chloro-5-fluoropyridin-3-yl)methyl methanesulfonate

Downstream raw materials:

5-fluoro-3-methylpyridin-2-amine

(5-fluoro-3-methyl-pyridin-2-yl)-hydrazine

5-fluoro-3-methylpicolinic acid

2-acetyl-5-fluoro-3-methyl-pyridine

Refernces

• 1、 -. "NOVEL COMPOUNDS". Page/Page column 20. . Retrieved 2009/02/11.
• 2、 -. "2-SUBSTITUTED PROPOXY-3-CYANO-5-HYDROXYPYRIDINES AND USE AS ANTIHYPERTENSIVES". . . Retrieved 2008/06/13.