2-Chloro-4-fluoropyridine

Base Information

• Chemical Name: 2-Chloro-4-fluoropyridine
• CAS No.: 34941-91-8
• Molecular Formula: C5H3ClFN
• Molecular Weight: 131.537
• Hs Code.: 29333990
• European Community (EC) Number: 675-788-8
• DSSTox Substance ID: DTXSID20382299
• Wikidata: Q72451331
• Mol file: 34941-91-8.mol

Synonyms:2-Chloro-4-fluoropyridine;34941-91-8;PYRIDINE, 2-CHLORO-4-FLUORO-;2-Chloro-4-fluoro-pyridine;MFCD04039345;2-Chlro-4-fluoroxypyridine;SCHEMBL45510;DTXSID20382299;FGSAQRJRWCZLOB-UHFFFAOYSA-N;BCP05875;STK664296;AKOS005064105;2-Chloro-4-fluoropyridine, AldrichCPR;AB17349;AS-8192;CS-W007987;AC-10871;Boc-(S)-3-Amino-4-(2-furyl)butanoicacid;A6132;AM20070068;C2627;FT-0639221;EN300-93196;J-400288

Chemical Property of 2-Chloro-4-fluoropyridine

Chemical Property:

• Vapor Pressure: 3.49mmHg at 25°C
• Refractive Index: 1.503
• Boiling Point: 157.9 °C at 760 mmHg
• PKA: 1.20±0.10(Predicted)
• Flash Point: 49.3 °C
• PSA: 12.89000
• Density: 0.997g/cm³
• LogP: 1.87410
• Storage Temp.: Room temperature.
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 130.9938050
• Heavy Atom Count: 8
• Complexity: 78.8

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-4-fluoropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, F
• Hazard Codes: Xi,F,Xn
• Statements: 20/21/22-36/37/38-10
• Safety Statements: 26-36/37/39-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C=C1F)Cl
• Uses: 2-Chloro-4-fluoropyridine is a useful research chemical.

Technology Process of 2-Chloro-4-fluoropyridine

There total 2 articles about 2-Chloro-4-fluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

2-chloro-4-nitropyridine (23056-36-2) → 2-chloro-4-fluoropyridine (34941-91-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; water; N,N-dimethyl-formamide; at 23 ℃; for 0.5h;

DOI:10.1021/ol047688v

Reference yield:

→ 2-chloro-4-fluoropyridine (34941-91-8)

Guidance literature:

entspr. Chlorpyridin, KF;

Reference yield: 100.0%

2-chloro-4-fluoropyridine (34941-91-8) + phenol (108-95-2,27073-41-2) → 2-chloro-4-(phenoxy)pyridine (334010-49-0)

Guidance literature:

phenol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.333333h;

2-chloro-4-fluoropyridine; In N,N-dimethyl-formamide; mineral oil; at 90 - 100 ℃;

DOI:10.1021/acs.jmedchem.8b01958

upstream raw materials:

2-chloro-4-nitropyridine

Downstream raw materials:

(1R,2R)-2-(6-(2-chloropyridin-4-yloxy)benzo[d]thiazol-2-ylamino)cyclohexanol

2-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)-5-(4-fluoropyridin-2-yl)oxazole

4-(4-fluoro-pyridin-2-yloxymethyl)-benzonitrile

2-chloro-4-(methylsulfanyl)pyridine

Refernces