4-Chloro-2-hydroxypyridine

Base Information

• Chemical Name: 4-Chloro-2-hydroxypyridine
• CAS No.: 40673-25-4
• Molecular Formula: C5H4ClNO
• Molecular Weight: 129.546
• Hs Code.: 2933399090
• European Community (EC) Number: 670-280-2
• DSSTox Substance ID: DTXSID70373970
• Nikkaji Number: J2.571.119J
• Wikidata: Q72451973
• Mol file: 40673-25-4.mol

Synonyms:4-Chloro-2-hydroxypyridine;40673-25-4;4-Chloropyridin-2-ol;4-chloro-1H-pyridin-2-one;2(1H)-Pyridinone, 4-chloro-;4-chloro-2(1H)-pyridinone;MFCD03093022;4-CHLORO-2(1H)-PYRIDONE;4-Chloro-2-pyridinol;2(1H)-Pyridinone,4-chloro-;4-chloropyridone;4-chloro pyridone;4-chloro-2-pyridone;2-hydroxy-4-chloro-pyridine;4-Chloro-2-hydroxy-pyridine;4-chloropyridin-2(1H)-one;SCHEMBL608199;DTXSID70373970;OZUXGFRLSKQVMI-UHFFFAOYSA-N;BBL102992;STL556801;4-Chloro-1,2-dihydropyridine-2-one;AKOS005199007;AB13188;AC-6269;CS-W019294;AS-17513;BP-20177;SY025321;A6794;AM20051167;C3120;FT-0618046;EN300-91227

Chemical Property of 4-Chloro-2-hydroxypyridine

Chemical Property:

• Vapor Pressure: 0.00204mmHg at 25°C
• Melting Point: 177-179 °C
• Refractive Index: 1.569
• Boiling Point: 309.09 °C at 760 mmHg
• PKA: 10.54±0.10(Predicted)
• Flash Point: 140.733 °C
• PSA: 33.12000
• Density: 1.35 g/cm³
• LogP: 1.44060
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 128.9981414
• Heavy Atom Count: 8
• Complexity: 171

Purity/Quality:

98% ^*data from raw suppliers

4-Chloro-2-hydroxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CNC(=O)C=C1Cl

Technology Process of 4-Chloro-2-hydroxypyridine

There total 3 articles about 4-Chloro-2-hydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

2,4-dichloropyridine (26452-80-2) → 4-chloropyridine-2-(1H)-one (40673-25-4)

Guidance literature:

With sodium acetate; acetic acid; at 150 ℃; for 72h; Sealed tube;

DOI:10.1055/s-0035-1560469

Reference yield:

4-Amino-2-chloropyridine (14432-12-3) → 4-chloropyridine-2-(1H)-one (40673-25-4)

Guidance literature:

Multi-step reaction with 2 steps

1: copper dichloride; tert.-butylnitrite / acetonitrile / 16 h / 0 - 20 °C

2: sodium acetate; acetic acid / 72 h / 150 °C / Sealed tube

With tert.-butylnitrite; sodium acetate; acetic acid; copper dichloride; In acetonitrile; 1: |Sandmeyer Reaction;

DOI:10.1055/s-0035-1560469

Reference yield:

→ 4-chloro-2-hydroxypyridine (40673-25-4)

Guidance literature:

With water;

upstream raw materials:

4-Amino-2-chloropyridine

2,4-dichloropyridine

Downstream raw materials:

N-benzyl-4-chloro-2-pyridinone

Refernces