C₄₉H₅₁BN₄O₇

Base Information

• Chemical Name: C₄₉H₅₁BN₄O₇
• CAS No.: 1417895-76-1
• Molecular Formula: C₄₉H₅₁BN₄O₇
• Molecular Weight: 818.778
• Mol file: 1417895-76-1.mol

Synonyms:C₄₉H₅₁BN₄O₇

Chemical Property of C₄₉H₅₁BN₄O₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₉H₅₁BN₄O₇

There total 5 articles about C₄₉H₅₁BN₄O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

C29H33BN2O4 (1417895-72-7) + (2S,4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester (174148-03-9) → C49H51BN4O7 (1417895-76-1)

Guidance literature:

C₂₉H₃₃BN₂O₄; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h;

(2S,4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester; With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; at 20 ℃; for 15h; pH=Ca. 7 - 8; Inert atmosphere;

Reference yield:

C24H25BN2O2 + (2S,4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester (174148-03-9) → C49H51BN4O7 (1417895-76-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; at 20 ℃; for 15h; pH=Ca. 7 - 8; Inert atmosphere;

DOI:10.1002/anie.201206374

Reference yield:

anthracenylmethyl chloride (24463-19-2) → C49H51BN4O7 (1417895-76-1)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 2.5 h / 90 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 2 h / 90 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 15 h / 20 °C / pH Ca_. 7 - 8 / Inert atmosphere

With triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1002/anie.201206374

upstream raw materials:

anthracenylmethyl chloride

(2S,4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

[2-((anthracen-9-ylmethyl)amino)ethyl]carbamic acid tert-butyl ester

C₂₉H₃₃BN₂O₄

Downstream raw materials:

C₄₄H₄₃BN₄O₅

C₆₅H₆₄B₂N₆O₁₀S

C₅₀H₅₄B₂N₆O₈S

Refernces

• 1、 Rout, Bhimsen,Unger, Linor,Armony, Gad,Iron, Mark A.,Margulies, David. "Medication detection by a combinatorial fluorescent molecular sensor". . p. 12477 - 12481. Retrieved 2013/02/23.