2-Chloro-5-(phenylmethoxy)-pyrimidine

Base Information

• Chemical Name: 2-Chloro-5-(phenylmethoxy)-pyrimidine
• CAS No.: 138274-14-3
• Molecular Formula: C11H9ClN2O
• Molecular Weight: 220.658
• Hs Code.: 2933599090
• Mol file: 138274-14-3.mol

Synonyms:5-(Benzyloxy)-2-chloropyrimidine;

Chemical Property of 2-Chloro-5-(phenylmethoxy)-pyrimidine

Chemical Property:

• Appearance/Colour: Yellow power
• Refractive Index: 1.593
• Boiling Point: 387 °C at 760 mmHg
• PKA: -1.28±0.22(Predicted)
• Flash Point: 187.9 °C
• PSA: 35.01000
• Density: 1.278 g/cm³
• LogP: 2.70900
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

5-(Benzyloxy)-2-chloropyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-5-(phenylmethoxy)-pyrimidine

There total 2 articles about 2-Chloro-5-(phenylmethoxy)-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzyl bromide (100-39-0) + 2-chloropyrimidine-5-ol (4983-28-2) → 5-(benzyloxy)-2-chloropyrimidine (138274-14-3)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 15 ℃; for 8h; Inert atmosphere;

Reference yield:

benzyl chloride (100-44-7) + 2-chloropyrimidine-5-ol (4983-28-2) → 5-(benzyloxy)-2-chloropyrimidine (138274-14-3)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 20 ℃; Reflux;

Reference yield: 96.0%

morpholine (110-91-8,99108-56-2) + 5-(benzyloxy)-2-chloropyrimidine (138274-14-3) → 4-(5-benzyloxypyrimidin-2-yl)morpholine

Guidance literature:

With potassium carbonate; In water; at 100 ℃; for 19h;

upstream raw materials:

benzyl bromide

2-chloropyrimidine-5-ol

benzyl chloride

Downstream raw materials:

1-(5-Benzyloxy-2-pyrimidinyl)piperazine

(1R*,2S*,3R*,4S*)-N-<4-<4-(5-Benzyloxy-2-pyrimidinyl)-1-piperazinyl>butyl>-2,3-bicyclo<2.2.1>heptanedicarboximide

5-[5-(benzyloxy)pyrimidin-2-ylamino]-2-fluoro-benzonitrile

[(3R,4S)-1-(5-benzyloxypyrimidin-2-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

Refernces

• 1、 -. "USE OF PYRIDYLOXYPYRIMIDINES FOR TREATING INFECTIOUS DISEASES". Paragraph 00145-00146. . Retrieved 2021/05/21.
• 2、 Kawada, Hiroyoshi,Kador, Peter F.. "Orally Bioavailable Metal Chelators and Radical Scavengers: Multifunctional Antioxidants for the Coadjutant Treatment of Neurodegenerative Diseases". . p. 8796 - 8805. Retrieved 2015/12/09.