2-Cyano-3-nitropyridine

Base Information

• Chemical Name: 2-Cyano-3-nitropyridine
• CAS No.: 51315-07-2
• Molecular Formula: C6H3N3O2
• Molecular Weight: 149.109
• Hs Code.: 2933399090
• Mol file: 51315-07-2.mol

Synonyms:Picolinonitrile,3-nitro- (6CI);3-Nitropicolinonitrile;

Chemical Property of 2-Cyano-3-nitropyridine

Chemical Property:

• Vapor Pressure: 0.009mmHg at 25°C
• Refractive Index: 1.653
• Boiling Point: 340.3 °C at 760 mmHg
• PKA: -4.35±0.10(Predicted)
• Flash Point: 159.6 °C
• PSA: 82.50000
• Density: 1.41 g/cm³
• LogP: 1.38468
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Cyano-3-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Cyano-3-nitropyridine

There total 6 articles about 2-Cyano-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-bromo-3-nitropyridine (19755-53-4) + copper(l) cyanide → 3-nitropyridine-2-carbonitrile (51315-07-2)

Guidance literature:

at 150 ℃; for 2h;

DOI:10.1016/j.ejmech.2012.10.006

Reference yield:

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) + copper(l) cyanide → 3-nitropyridine-2-carbonitrile (51315-07-2)

Guidance literature:

In dimethyl sulfoxide; at 120 ℃; for 16h; Inert atmosphere;

Reference yield:

2-amino-3-nitropyridine (4214-75-9) → 3-nitropyridine-2-carbonitrile (51315-07-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen bromide; potassium nitrite; copper(I) bromide / water; dimethyl sulfoxide / 4 h / 35 °C

2: 2 h / 150 °C

With potassium nitrite; hydrogen bromide; copper(I) bromide; In water; dimethyl sulfoxide;

DOI:10.1016/j.ejmech.2012.10.006

upstream raw materials:

2-bromo-3-nitropyridine

2-hydroxy-3-nitropyridine

2-amino-3-nitropyridine

2-Chloro-3-nitropyridine

Downstream raw materials:

3-Nitropyridin-2-carboxamid

3-methoxy-pyridine-2-carbonitrile

3-hydroxypyridine-2-carbonitrile

3-fluoropicolinonitrile

Refernces

• 1、 Loidreau, Yvonnick,Marchand, Pascal,Dubouilh-Benard, Carole,Nourrisson, Marie-Renée,Duflos, Muriel,Lozach, Olivier,Loa?c, Nadège,Meijer, Laurent,Besson, Thierry. "Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d] pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors". . p. 171 - 183. Retrieved 2013/02/22.