N-Cyclobutyl-4-piperidone

Base Information

• Chemical Name: N-Cyclobutyl-4-piperidone
• CAS No.: 359880-05-0
• Molecular Formula: C9H15NO
• Molecular Weight: 153.224
• Hs Code.: 2933399090
• Mol file: 359880-05-0.mol

Synonyms:1-Cyclobutyl-4-piperidone;

Chemical Property of N-Cyclobutyl-4-piperidone

Chemical Property:

• Vapor Pressure: 0.018mmHg at 25°C
• Refractive Index: 1.536
• Boiling Point: 253.828 °C at 760 mmHg
• Flash Point: 100.005 °C
• PSA: 20.31000
• Density: 1.105 g/cm³
• LogP: 1.14170
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-Cyclobutylpiperidin-4-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Cyclobutyl-4-piperidone

There total 3 articles about N-Cyclobutyl-4-piperidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclobutylamine (2516-34-9) → 1-cyclobutyl-4-oxo-piperidine (359880-05-0)

Guidance literature:

With potassium carbonate; In ethanol; for 1.5h; Heating / reflux;

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) + cyclobutylamine (2516-34-9) → 1-cyclobutyl-4-oxo-piperidine (359880-05-0)

Guidance literature:

1-phenylmethyl-4-piperidone; With methyl iodide; In acetone; for 3h;

cyclobutylamine; With potassium carbonate; In ethanol; for 1.5h; Reflux;

Reference yield:

→ 1-cyclobutyl-4-oxo-piperidine (359880-05-0)

Guidance literature:

upstream raw materials:

cyclobutylamine

1-phenylmethyl-4-piperidone

Downstream raw materials:

4-(4-methylbenzylamino)-1-cyclobutylpiperidine

2-(4-methoxyphenyl)-N-(4-methylbenzyl)-N-(1-cyclobutylpiperidin-4-yl)acetamide oxalate

2-(4-chlorophenyl)-N-(4-methylbenzyl)-N-(1-cyclobutylpiperidin-4-yl)-acetamide oxalate

2-(4-Chlorophenyl)-N-(4-methylbenzyl)-N-(1-cyclobutylpiperidin-4-yl)-acetamide

Refernces

• 1、 -. "USE OF 4-AMINO-PIPERIDINES FOR TREATING SLEEP DISORDERS". Page/Page column 136. . Retrieved 2010/11/28.