Seserine

Base Information Edit

Chemical Name:Seserine
CAS No.:79617-89-3
Molecular Formula:C17H17Cl2N^.HCl
Molecular Weight:342.696
Hs Code.:2921490002
Mol file:79617-89-3.mol

Synonyms:Altruline;Apo Sertraline;Apo-Sertraline;Aremis;Besitran;Gen Sertraline;Gen-Sertraline;Gladem;Hydrochloride, Sertraline;Lustral;Novo Sertraline;Novo-Sertraline;ratio Sertraline;ratio-Sertraline;Rhoxal sertraline;Rhoxal-sertraline;Sealdin;Sertraline;Sertraline Hydrochloride;Sertraline Hydrochloride (1S-cis)-Isomer;Zoloft

Suppliers and Price of Seserine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
rac-cis-SertralineHydrochloride
250mg
$ 1355.00

Sigma-Aldrich
Sertraline hydrochloride racemic mixture United States Pharmacopeia (USP) Reference Standard
30mg
$ 1160.00

Medical Isotopes, Inc.
rac-cis-SertralineHCl
250 mg
$ 2120.00

Chemtos
Sertraline-d7HCl0.1mg/ml
1ml of 0.1 mg
$ 150.00

Total 30 raw suppliers

Chemical Property of Seserine Edit

Chemical Property:

Vapor Pressure:2.78E-08mmHg at 25°C
Melting Point:275-277 °C
Boiling Point:443.8 °C at 760 mmHg
Flash Point:222.2 °C
PSA：12.03000
LogP:6.37250
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:341.050483
Heavy Atom Count:21
Complexity:322

Purity/Quality:

99.9% ^*data from raw suppliers

rac-cis-SertralineHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-52/53

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C[NH2+]C1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.[Cl-]
Isomeric SMILES:C[NH2+][C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.[Cl-]

Technology Process of Seserine

There total 8 articles about Seserine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

: 261776-41-4
(4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-ylidene)methylamine

: C₁₇H₁₈ClN

: 79617-89-3
cis-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthaleneamine hydrochloride

Guidance literature:: (4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-ylidene)methylamine; With hydrogen; palladium on activated charcoal; In toluene; for 3 - 4h; under 155.149 - 206.865 Torr;

With hydrogenchloride; In water; toluene; at 35 - 40 ℃; pH=1 - 2; Product distribution / selectivity;

Reference yield: 79.0%

: 140631-53-4
sertraline

: 79617-89-3
cis-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthaleneamine hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; at 0 - 10 ℃; for 2h;

Reference yield:

: 79836-45-6
trans-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

: 79617-89-3
cis-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthaleneamine hydrochloride

Guidance literature:: trans-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine; With potassium hydroxide; In pyridine; water; at 115 - 120 ℃; for 20 - 25h;

With hydrogenchloride; In methanol; water; Product distribution / selectivity;