2,6-Dichloropyridine-4-methylamine

Base Information

• Chemical Name: 2,6-Dichloropyridine-4-methylamine
• CAS No.: 88579-63-9
• Molecular Formula: C6H6 Cl2 N2
• Molecular Weight: 177.033
• Hs Code.: 2933399090
• European Community (EC) Number: 810-575-7
• DSSTox Substance ID: DTXSID20465379
• Wikidata: Q72468003
• Mol file: 88579-63-9.mol

Synonyms:4-(Aminomethyl)-2,6-dichloropyridine

Chemical Property of 2,6-Dichloropyridine-4-methylamine

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Boiling Point: 291.912oC at 760 mmHg
• Flash Point: 130.344oC
• PSA: 38.91000
• Density: 1.399g/cm3
• LogP: 2.54740
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 175.9908036
• Heavy Atom Count: 10
• Complexity: 99.9

Purity/Quality:

99% ^*data from raw suppliers

2,6-Dichloropyridine-4-methylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(N=C1Cl)Cl)CN

Technology Process of 2,6-Dichloropyridine-4-methylamine

There total 4 articles about 2,6-Dichloropyridine-4-methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,6-dichloro-4-cyanopyridine (32710-65-9) → (2,6-dichloropyridin-4-yl)methanamine (88579-63-9)

Guidance literature:

With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 20 ℃; for 17.5h;

Reference yield:

2,6-dichloropyridine-4-carboxamide (89281-13-0) → (2,6-dichloropyridin-4-yl)methanamine (88579-63-9)

Guidance literature:

Multi-step reaction with 2 steps

1: P₂O₅ / unter vermindertem Druck

2: SnCl₂; HCl; diethyl ether

With hydrogenchloride; diethyl ether; phosphorus pentoxide; tin(ll) chloride;

Reference yield:

2,6-dichloropyridine-4-carboxylic acid (5398-44-7) → (2,6-dichloropyridin-4-yl)methanamine (88579-63-9)

Guidance literature:

Multi-step reaction with 4 steps

1: SOCl₂

3: P₂O₅ / unter vermindertem Druck

4: SnCl₂; HCl; diethyl ether

With hydrogenchloride; thionyl chloride; diethyl ether; phosphorus pentoxide; tin(ll) chloride;

upstream raw materials:

2,6-dichloro-4-cyanopyridine

2,6-dichloropyridine-4-carboxamide

2,6-dichloropyridine-4-carboxylic acid

2,6-dichloroisonicotinoyl chloride

Downstream raw materials:

(2,6-dichloropyridin-4-yl)methanol

Refernces