isopropyl 2-(4-iodophenoxy)-2-methylpropanoate

Base Information

• Chemical Name: isopropyl 2-(4-iodophenoxy)-2-methylpropanoate
• CAS No.: 1375008-18-6
• Molecular Formula: C₁₃H₁₇IO₃
• Molecular Weight: 348.181
• Mol file: 1375008-18-6.mol

Synonyms:isopropyl 2-(4-iodophenoxy)-2-methylpropanoate

Chemical Property of isopropyl 2-(4-iodophenoxy)-2-methylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of isopropyl 2-(4-iodophenoxy)-2-methylpropanoate

There total 1 articles about isopropyl 2-(4-iodophenoxy)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

isopropyl 2-bromo-2?methylpropanoate (51368-55-9) + p-Iodophenol (540-38-5) → isopropyl 2-(4-iodophenoxy)-2-methylpropanoate (1375008-18-6)

Guidance literature:

With potassium hydroxide; In ethanol; for 24h; Reflux;

DOI:10.1039/c9sc01817d

Reference yield: 91.0%

isopropyl 2-(4-iodophenoxy)-2-methylpropanoate (1375008-18-6) + 9-methyl-9H-fluorene-9-carbonyl chloride (82102-37-2) → isopropyl 2-(4-formylphenoxy)-2-methylpropanoate (1440912-09-3)

Guidance literature:

With dichloro(1,5-cyclooctadiene)palladium(II); N-Methyldicyclohexylamine; potassium formate; tetra-(n-butyl)ammonium iodide; tricyclohexylphosphine tetrafluoroborate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In acetonitrile; at 80 ℃; for 18h; Sealed tube; Glovebox; Inert atmosphere;

DOI:10.1021/jo400741t

Reference yield: 90.0%

isopropyl 2-(4-iodophenoxy)-2-methylpropanoate (1375008-18-6) + 4-Chlorophenylboronic acid (1679-18-1) + molybdenum hexacarbonyl (13939-06-5,199620-15-0) → fenofibrate (49562-28-9)

Guidance literature:

With potassium phosphate; palladium(II) trifluoroacetate; In water; acetonitrile; at 50 ℃; for 6h; Inert atmosphere; Sealed tube;

DOI:10.1002/adsc.201900011

upstream raw materials:

isopropyl 2-bromo-2?methylpropanoate

p-Iodophenol

Downstream raw materials:

(E)-isopropyl 2-(4-(3-butoxyacryloyl)phenoxy)-2-methylpropanoate

fenofibrate

isopropyl 2-(4-formylphenoxy)-2-methylpropanoate

[D]-ropyl 2-(4-formylphenoxy)-2-methylpropanoate

Refernces

• 1、 Lutter, Ferdinand H.,Grokenberger, Lucie,Hofmayer, Maximilian S.,Knochel, Paul. "Cobalt-catalyzed acylation-reactions of (hetero)arylzinc pivalates with thiopyridyl ester derivatives". . p. 8241 - 8245. Retrieved 2019/09/19.