4,6-Dimethoxy-2-methylpyrimidine

Base Information

• Chemical Name: 4,6-Dimethoxy-2-methylpyrimidine
• CAS No.: 13566-48-8
• Molecular Formula: C₇H₁₀N₂O₂
• Molecular Weight: 154.169
• Hs Code.: 2933599090
• DSSTox Substance ID: DTXSID00452904
• Wikidata: Q72468062
• Mol file: 13566-48-8.mol

Synonyms:4,6-Dimethoxy-2-methylpyrimidine;13566-48-8;2-methyl-4,6-dimethoxypyrimidine;Pyrimidine, 4,6-dimethoxy-2-methyl-;4,6-dimethoxy-2-methyl-pyrimidine;SCHEMBL423183;DTXSID00452904;FWQJAXMTUACMLK-UHFFFAOYSA-N;MFCD06657567;AKOS006292335;AC-9319;SB57761;AS-11878;2-methyl-4 pound not6-dimethoxypyrimidine;CS-0045638;FT-0636921

Chemical Property of 4,6-Dimethoxy-2-methylpyrimidine

Chemical Property:

• Vapor Pressure: 0.076mmHg at 25°C
• Melting Point: 52-53 °C
• Boiling Point: 314.4°Cat760mmHg
• PKA: 1.84±0.30(Predicted)
• Flash Point: 143.9°C
• PSA: 44.24000
• Density: 1.44g/cm³
• LogP: 0.80220
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 154.074227566
• Heavy Atom Count: 11
• Complexity: 109

Purity/Quality:

99% ^*data from raw suppliers

2-Methyl-4,6-dimethoxypyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=CC(=N1)OC)OC

Technology Process of 4,6-Dimethoxy-2-methylpyrimidine

There total 2 articles about 4,6-Dimethoxy-2-methylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichloro-2-methylpyrimidine (1780-26-3) + sodium methylate (124-41-4) → 2-methyl-4,6-dimethoxypyrimidine (13566-48-8)

Guidance literature:

With methanol;

Reference yield:

→ 2-methyl-4,6-dimethoxypyrimidine (13566-48-8)

Guidance literature:

2-Methyl-4,6-dichlor-pyrimidin, NaOCH3;

Reference yield:

2-methyl-4,6-dimethoxypyrimidine (13566-48-8) → 2-hydroxymethyl-4,6-dimethoxypyrimidine (125966-88-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 48 percent / benzoyl peroxide, NBS / CCl₄ / 14 h / Ambient temperature

2: 88 percent / ethanol / 4 h / Heating

3: 40 percent / K₂CO₃ / methanol / 12 h / Ambient temperature

With N-Bromosuccinimide; potassium carbonate; dibenzoyl peroxide; In methanol; tetrachloromethane; ethanol;

DOI:10.1002/jhet.5570260406

upstream raw materials:

2,4-dichloro-2-methylpyrimidine

sodium methylate

Downstream raw materials:

2-hydroxymethyl-4,6-dimethoxypyrimidine

(4,6-Dimethoxypyrimidin-2-yl)essigsaeure