9,9-Dimethyl-9H-fluoren-2-yl-boronic acid

Base Information

• Chemical Name: 9,9-Dimethyl-9H-fluoren-2-yl-boronic acid
• CAS No.: 333432-28-3
• Molecular Formula: C15H15BO2
• Molecular Weight: 238.094
• Hs Code.: 2931900090
• Mol file: 333432-28-3.mol

Synonyms:Boronicacid, (9,9-dimethyl-9H-fluoren-2-yl)- (9CI);9,9-Dimethyl-2-fluoreneboronicacid;9,9-Dimethyl-9H-fluoren-2-yl-2-boronic acid;

Chemical Property of 9,9-Dimethyl-9H-fluoren-2-yl-boronic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 300 °C
• Refractive Index: 1.628
• Boiling Point: 436.453 °C at 760 mmHg
• PKA: 8.62±0.40(Predicted)
• Flash Point: 217.759 °C
• PSA: 40.46000
• Density: 1.2 g/cm³
• LogP: 1.67270
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

9,9-Dimethyl-9h-fluoren-2-ylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 9,9-Dimethyl-9h-fluoren-2-ylboronic acid

Technology Process of 9,9-Dimethyl-9H-fluoren-2-yl-boronic acid

There total 9 articles about 9,9-Dimethyl-9H-fluoren-2-yl-boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Trimethyl borate (121-43-7,63156-11-6) + 2-bromo-9,9-dimethyl-9H-fluorene (28320-31-2) → 9,9-dimethyl-9H-fluoren-2-yl-2-boronic acid (333432-28-3)

Guidance literature:

2-bromo-9,9-dimethyl-9H-fluorene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

Trimethyl borate; at 20 ℃; for 1h;

Reference yield: 77.0%

2-bromo-9,9-dimethyl-9H-fluorene (28320-31-2) → 9,9-dimethyl-9H-fluoren-2-yl-2-boronic acid (333432-28-3)

Guidance literature:

2-bromo-9,9-dimethyl-9H-fluorene; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

With Trimethyl borate; In tetrahydrofuran; for 0.5h;

With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield: 76.9%

Trimethyl borate (121-43-7,63156-11-6) + 2-bromo-9,9-dimethyl-9H-fluorene (28320-31-2) + water (7732-18-5) → 9,9-dimethyl-9H-fluoren-2-yl-2-boronic acid (333432-28-3)

Guidance literature:

2-bromo-9,9-dimethyl-9H-fluorene; With n-butyllithium; In tetrahydrofuran; hexane; at -70 - 0 ℃; for 1h; Inert atmosphere;

Trimethyl borate; In tetrahydrofuran; hexane; at 20 ℃; for 12h; Inert atmosphere;

water; With hydrogenchloride; In tetrahydrofuran; hexane; Inert atmosphere;

upstream raw materials:

2-iodo-9,9-dimethyl-9H-fluorene

2-bromo-9,9-dimethyl-9H-fluorene

Trimethyl borate

9,9-dimethylfluorenyl-2-boronic acid dimethyl ester

Downstream raw materials:

C₂₄H₁₉N

C₃₅H₂₅Br

C₃₅H₂₇BO₂

C₆₅H₄₄

Refernces

• 1、 -. "Naphtho-fluorene carbazole compound and application thereof". Paragraph 0097; 0100-0102. . Retrieved 2018/03/26.
• 2、 Hosseinzadeh, Rahman,Mohadjerani, Maryam,Pooryousef, Mona. "Fluorene-based boronic acids as fluorescent chemosensor for monosaccharides at physiological pH". . p. 549 - 555. Retrieved 2015/12/04.