Technology Process of 2-((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy) thyl carbonate
There total 22 articles about 2-((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy) thyl carbonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: N,N-dimethyl-formamide; toluene / 5 h / 110 °C
2.1: palladium 10% on activated carbon; hydrogen / methanol / 14 h / 20 °C
3.1: N-ethyl-N,N-diisopropylamine / 4-methyl-2-pentanone / 2 h / 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -30 °C
4.2: 3 h / 20 °C
5.1: lithium borohydride / tetrahydrofuran / 5 h / 0 °C
6.1: 5%-palladium/activated carbon / methanol / 1 h / 20 °C
7.1: triethylamine; sodium iodide / 1,4-dioxane / 7 h / 120 °C
8.1: sodium nitrite / water; acetic acid; ethyl acetate / 30 °C
9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h
10.1: triethylamine / acetonitrile / 0.5 h / 20 °C
10.2: 2 h / 20 °C
11.1: iodine / methanol / 4 h / 60 °C
With
lithium borohydride; palladium 10% on activated carbon; 5%-palladium/activated carbon; hydrogen; iodine; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium nitrite;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; 4-methyl-2-pentanone; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2012.04.050
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h
2.1: triethylamine / acetonitrile / 0.5 h / 20 °C
2.2: 2 h / 20 °C
3.1: iodine / methanol / 4 h / 60 °C
With
iodine; triethylamine; N-ethyl-N,N-diisopropylamine;
In
methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2012.04.050
