Doxazosin hydrochloride

Base Information

• Chemical Name: Doxazosin hydrochloride
• CAS No.: 70918-01-3
• Molecular Formula: C23H25N5O5^.HCl
• Molecular Weight: 487.943
• European Community (EC) Number: 615-212-4
• UNII: Y9EDC2483R
• DSSTox Substance ID: DTXSID00469077
• Mol file: 70918-01-3.mol

Synonyms:Doxazosin hydrochloride;70918-01-3;Y9EDC2483R;(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanone hydrochloride(1:x);[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone;hydrochloride;Methanone, (4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl)(2,3-dihydro-1,4-benzodioxin-2-yl)-, hydrochloride (1:1);Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl)-, monohydrochloride;Piperazine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]-, monohydrochloride;UNII-Y9EDC2483R;SCHEMBL612310;UK 33274 HCl;DTXSID00469077;AQAZIYFEPYHLHC-UHFFFAOYSA-N;BCP13420;AKOS015896153;AC-11909;FT-0659869;A837025;(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanone hydrochloride;[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone hydrochloride;4-amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazoline hydrochloride

Chemical Property of Doxazosin hydrochloride

Chemical Property:

• Vapor Pressure: 1.83E-20mmHg at 25°C
• Boiling Point: 718 °C at 760 mmHg
• Flash Point: 388 °C
• PSA: 112.27000
• LogP: 3.10390
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 4
• Exact Mass: 487.1622466
• Heavy Atom Count: 34
• Complexity: 678

Purity/Quality:

98%,99%, ^*data from raw suppliers

DoxazosinHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC.Cl
• Uses: Doxazosin Hydrochloride can be used for the identical antagonist selectivity of central and peripheral α1-?adrenoceptors.

Technology Process of Doxazosin hydrochloride

There total 1 articles about Doxazosin hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

→ 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazoline hydrochloride (70918-01-3,105314-71-4) + (2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone (70918-00-2)

Guidance literature:

Refernces