2-Ethyl-1,4-dimethoxybenzene

Base Information

• Chemical Name: 2-Ethyl-1,4-dimethoxybenzene
• CAS No.: 1199-08-2
• Molecular Formula: C10H14O2
• Molecular Weight: 166.22
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID50343777
• Nikkaji Number: J1.455.159J
• Wikidata: Q72474467
• Mol file: 1199-08-2.mol

Synonyms:2-Ethyl-1,4-dimethoxybenzene;1199-08-2;1,4-Dimethoxy-2-ethylbenzene;Benzene, 2-ethyl-1,4-dimethoxy-;MFCD00672999;2-ethyl-1,4-dimethoxy-benzene;SCHEMBL805159;DTXSID50343777;2-Ethyl-1,4-dimethoxybenzene #;Benzene, 2-ethyl-1,4-dimethoxy;STK691288;AKOS005603422;CCG-356753;NS-01341;FT-0704323;Y14613;A804394

Chemical Property of 2-Ethyl-1,4-dimethoxybenzene

Chemical Property:

• Vapor Pressure: 0.0817mmHg at 25°C
• Refractive Index: 1.489
• Boiling Point: 234.2 °C at 760 mmHg
• Flash Point: 84.3 ºC
• PSA: 18.46000
• Density: 0.976 g/cm³
• LogP: 2.26620
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 166.099379685
• Heavy Atom Count: 12
• Complexity: 125

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Ethyl-1,4-dimethoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=C(C=CC(=C1)OC)OC

Technology Process of 2-Ethyl-1,4-dimethoxybenzene

There total 5 articles about 2-Ethyl-1,4-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2',5'-dimethoxyacetophenone (1201-38-3) → ethylhydroquinone dimethyl ether (1199-08-2)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; In various solvent(s); for 5h; Heating;

DOI:10.1021/jo00387a035

Reference yield: 26.0%

2,5-dimethoxybenzyl bromide (60732-17-4) + methylmagnesium bromide (75-16-1) → ethylhydroquinone dimethyl ether (1199-08-2) + 2,5,2',5'-tetramethoxy-bibenzyl (20306-76-7)

Guidance literature:

In diethyl ether; for 2h; Heating;

DOI:10.1021/jm00127a039

Reference yield:

1,4-dimethoxybezene (150-78-7) → ethylhydroquinone dimethyl ether (1199-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃ / CH₂Cl₂

2: Zn-Hg, aq. HCl / ethanol

With hydrogenchloride; aluminium trichloride; mercury; zinc; In ethanol; dichloromethane;

DOI:10.1021/jm00246a006

upstream raw materials:

2',5'-dimethoxyacetophenone

2-ethylhydroquinone

dimethyl sulfate

2,5-dimethoxybenzyl bromide

Downstream raw materials:

2-ethylnaphthazarin

4-(4-ethyl-2,5-dimethoxy-phenyl)-4-oxo-butyric acid

1-<4-Aethyl-2-hydroxy-5-methoxy-phenyl>-aethan-1-on

5,5'-diethyl-2,2'-bis-p-benzoquinone

Refernces

• 1、 Buu-Hoi,Cagniant. "-". . p. 53,62. Retrieved 1948.
• 2、 Roberts, William P.,Ebner, Cynthia L.. "Synthesis of Monoalkyl Derivatives of 7,7,8,8-Tetracyano-p-quinodimethane from 2,5-Dimethoxybenzoic Acid". . p. 2297 - 2299. Retrieved 2007/10/02.