2-Fluoro-6-methyl-3-nitropyridine

Base Information

• Chemical Name: 2-Fluoro-6-methyl-3-nitropyridine
• CAS No.: 19346-45-3
• Molecular Formula: C6H5FN2O2
• Molecular Weight: 156.116
• Hs Code.: 2933399090
• European Community (EC) Number: 675-121-0
• DSSTox Substance ID: DTXSID90382488
• Wikidata: Q72474712
• Mol file: 19346-45-3.mol

Synonyms:2-fluoro-6-methyl-3-nitropyridine;19346-45-3;2-fluoro-3-nitro-6-picoline;2-Fluoro-3-nitro-6-methylpyridine;Pyridine, 2-fluoro-6-methyl-3-nitro-;2-fluoro-6-methyl-3-nitro-pyridine;2-Fluoro-6-Methyl-3-Nitro pyridine;MFCD03095067;SCHEMBL9982714;DTXSID90382488;BCCWOQXQVNCXKC-UHFFFAOYSA-N;BCP22182;AKOS006229423;2-fluoranyl-6-methyl-3-nitro-pyridine;AC-5404;AM62412;GS-3410;934542-72-0;A4259;CS-0007516;FT-0637832;2-Fluoro-6-methyl-3-nitropyridine, AldrichCPR;A813645;W-206429

Chemical Property of 2-Fluoro-6-methyl-3-nitropyridine

Chemical Property:

• Melting Point: 30℃
• Boiling Point: 266.236 °C at 760 mmHg
• PKA: -3.74±0.10(Predicted)
• Flash Point: 114.816 °C
• PSA: 58.71000
• Density: 1.358 g/cm³
• LogP: 1.96050
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Slightly soluble in water.
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 156.03350557
• Heavy Atom Count: 11
• Complexity: 159

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Fluoro-6-methyl-3-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=C(C=C1)[N+](=O)[O-])F
• Uses: 6-Methyl-3-nitro-2-(2-phenylhydrazinyl)pyridine (MNPHP) was synthesized from 2-fluoro-3-nitro-6-methylpyridine.

Technology Process of 2-Fluoro-6-methyl-3-nitropyridine

There total 2 articles about 2-Fluoro-6-methyl-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Amino-6-methylpyridine (1824-81-3) → 2-fluoro-3-nitro-6-methylpyridine (19346-45-3)

Guidance literature:

2-Amino-6-methylpyridine; With sulfuric acid; nitric acid;

With hydrogen fluoride; Orthoboric acid;

With NaNO₂;

DOI:10.1016/j.molstruc.2022.132535

Reference yield:

→ 2-fluoro-3-nitro-6-methylpyridine (19346-45-3)

Guidance literature:

aus 2-Amino-3-nitro-6-methylpyridin und NaNO2 u. wss. HF;

Reference yield: 93.0%

2-fluoro-3-nitro-6-methylpyridine (19346-45-3) → 6-amino-5-nitro-2-picoline (21901-29-1)

Guidance literature:

With ammonium hydroxide; In water; at 130 ℃; for 0.5h; Microwave irradiation;

DOI:10.1021/acs.jmedchem.7b01691

upstream raw materials:

2-Amino-6-methylpyridine

Downstream raw materials:

1-(2-chloro-benzyl)-5-fluoro-3-(6'-methyl-3'-nitro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-1,3-dihydro-benzoimidazol-2-ylideneamine

6-methyl-3-nitro-2-(2-phenylhydrazinyl)pyridine

2,3-diamino-6-methyl-pyridine

6-amino-5-nitro-2-picoline

Refernces