5-Fluoro-2,3-dihydrobenzo[b]furan

Base Information

• Chemical Name: 5-Fluoro-2,3-dihydrobenzo[b]furan
• CAS No.: 245762-35-0
• Molecular Formula: C8H7FO
• Molecular Weight: 138.141
• Hs Code.: 2932999099
• Mol file: 245762-35-0.mol

Synonyms:5-Fluoro-2,3-dihydrobenzofuran;

Chemical Property of 5-Fluoro-2,3-dihydrobenzo[b]furan

Chemical Property:

• Vapor Pressure: 0.711mmHg at 25°C
• Refractive Index: 1.535
• Boiling Point: 191.559 °C at 760 mmHg
• Flash Point: 67.719 °C
• PSA: 9.23000
• Density: 1.214 g/cm³
• LogP: 1.76060
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

5-Fluoro-2,3-dihydrobenzofuran ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Fluoro-2,3-dihydrobenzo[b]furan is a useful research chemical.

Technology Process of 5-Fluoro-2,3-dihydrobenzo[b]furan

There total 13 articles about 5-Fluoro-2,3-dihydrobenzo[b]furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5-Fluoro[b]benzofuran (24410-59-1) → 5-fluoro-2,3-dihydrobenzofuran (245762-35-0)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; for 12h; under 2585.74 Torr;

DOI:10.1021/jm0304010

Reference yield: 65.0%

2-(3-fluorophenyl)ethanol (52059-53-7) → 5-fluoro-2,3-dihydrobenzofuran (245762-35-0)

Guidance literature:

2-(3-fluorophenyl)ethanol; With [hydroxy(tosyloxy)iodo]benzene; triethylamine; at 23 ℃; for 8h; Inert atmosphere;

With copper(II) hexafluoroacetylacetonate; In 2,2,2-trifluoroethanol; at 23 ℃; for 12h; Inert atmosphere;

DOI:10.1002/anie.201605648

Reference yield: 57.0%

1-bromo-5-fluoro-2-methoxy-3-methylbenzene → 5-fluoro-2,3-dihydrobenzofuran (245762-35-0)

Guidance literature:

With palladium⁽⁰⁾bis(tricyclohexylphosphine); cesium pivalate; In toluene; at 140 ℃; for 16h; Inert atmosphere; Sealed tube; Glovebox;

DOI:10.1002/anie.201908460

upstream raw materials:

5-Fluoro[b]benzofuran

4-Fluorophenol

2-(4-Fluorophenoxy)-acetaldehyde Diethyl Acetal

2,3-dihydro-1-benzofuran-5-amine

Downstream raw materials:

5-fluoro-7-hydroxy-2,3-dihydrobenzofuran

5-fluoro-2,3-dihydrobenzofuran-7-carbaldehyde

Refernces

• 1、 Rocaboy, Ronan,Anastasiou, Ioannis,Baudoin, Olivier. "Redox-Neutral Coupling between Two C(sp3)?H Bonds Enabled by 1,4-Palladium Shift for the Synthesis of Fused Heterocycles". supporting information. p. 14625 - 14628. Retrieved 2019/09/16.
• 2、 Patel, Maulik R.,Bhatt, Aaditya,Steffen, Jamin D.,Chergui, Adel,Murai, Junko,Pommier, Yves,Pascal, John M.,Trombetta, Louis D.,Fronczek, Frank R.,Talele, Tanaji T.. "Discovery and structure-activity relationship of novel 2,3- dihydrobenzofuran-7-carboxamide and 2,3-dihydrobenzofuran-3(2 h)-one-7-carboxamide derivatives as poly(ADP-ribose)polymerase-1 Inhibitors". . p. 5579 - 5601. Retrieved 2014/08/05.