4-Fluoroindoline-2,3-dione

Base Information

• Chemical Name: 4-Fluoroindoline-2,3-dione
• CAS No.: 346-34-9
• Molecular Formula: C8H4FNO2
• Molecular Weight: 165.12
• Hs Code.: 2933990090
• Mol file: 346-34-9.mol

Synonyms:Isatin,4-fluoro- (6CI);4-Fluoroisatin;

Chemical Property of 4-Fluoroindoline-2,3-dione

Chemical Property:

• Refractive Index: 1.584
• PKA: 8.56±0.20(Predicted)
• PSA: 46.17000
• Density: 1.477 g/cm³
• LogP: 1.09850
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Fluoroindoline-2,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Fluoroindoline-2,3-dione

There total 11 articles about 4-Fluoroindoline-2,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

→ 4-fluoro-1H-indole-2,3-dione (346-34-9)

Guidance literature:

With peracetic acid; copper(l) iodide; In ethanol; at 60 ℃; for 0.166667h; Microwave irradiation;

Reference yield: 56.0%

4-fluoroindole (387-43-9) → 4-fluoro-1H-indole-2,3-dione (346-34-9)

Guidance literature:

4-fluoroindole; With N-Bromosuccinimide; dimethyl sulfoxide; at 80 ℃; for 3h; under 600.06 Torr; Inert atmosphere;

With pyridine; In dimethyl sulfoxide; at 80 ℃; for 2h; Solvent; Reagent/catalyst;

Reference yield: 52.9%

meta-fluoroaniline (372-19-0) + chloral hydrate (302-17-0) → 4-fluoro-1H-indole-2,3-dione (346-34-9)

Guidance literature:

meta-fluoroaniline; chloral hydrate; With hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate; In water; at 35 - 85 ℃; for 4h;

With sulfuric acid; In water; at 80 ℃; for 1h;

With acetic acid; sodium hydroxide; at 50 ℃;

upstream raw materials:

(2E)-N-(3-fluorophenyl)-2-hydroxyiminoacetamide

3-fluoro-isonitrosoacetanilide

meta-fluoroaniline

1-fluoro-2-methyl-3-nitrobenzene

Downstream raw materials:

C₁₀H₆FNO₂

Refernces

• 1、 -. "Method for preparing indole-2,3-dione derivatives by catalytic oxidation of microwave copper/peroxyacetic acid". Paragraph 0024; 0035. . Retrieved 2018/09/08.
• 2、 -. "METHOD FOR PRODUCING 4-FLUOROISATIN DERIVATIVE". Paragraph 0111. . Retrieved 2017/02/09.