1-(4-Fluorophenyl)piperazine dihydrochloride

Base Information

• Chemical Name: 1-(4-Fluorophenyl)piperazine dihydrochloride
• CAS No.: 64090-19-3
• Molecular Formula: C10H14N5O4
• Molecular Weight: 253.147
• Hs Code.: 29335990
• Mol file: 64090-19-3.mol

Synonyms:1-(4-Fluorophenyl)piperazine 2HCl;

Chemical Property of 1-(4-Fluorophenyl)piperazine dihydrochloride

Chemical Property:

• Vapor Pressure: 1.78E-05mmHg at 25°C
• Melting Point: 231-234 °C
• Boiling Point: 363.6 °C at 760 mmHg
• Flash Point: 137.8 °C
• PSA: 15.27000
• LogP: 3.23310
• Storage Temp.: Store below +30°C.

Purity/Quality:

98.0% Min., ^*data from raw suppliers

1-(4-Fluorophenyl)piperazine dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T, Xi
• Hazard Codes: T,Xi
• Statements: 23/24/25-36/37/38-25
• Safety Statements: 22-26-36/37/39-45-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Phenylpiperazines are entactogenic drugs which direct central serotonin release. Substituted phenylpiperazines, such as 1-(3-chlorophenyl)piperazine, have been identified as designer drugs or drugs of abuse. 1-(4-Fluorophenyl)piperazine dihydrochloride is a substituted phenylpiperazine with a potential for abuse. The physiological and toxicological properties of this compound have not been evaluated. This product is intended for forensic and research applications. 1-(4-Fluorophenyl)piperazine is a major metabolite of Niaparazine, a sedative, hypnotic drug. Metabolites of Niaprazine occurred by N-dealkylation, N-dearylation, aromatic hydroxylation and N-oxidation.

Technology Process of 1-(4-Fluorophenyl)piperazine dihydrochloride

There total 1 articles about 1-(4-Fluorophenyl)piperazine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis-(2-chloroethyl)amine hydrochloride (821-48-7) + 4-fluoroaniline (371-40-4) → 1-(4-fluorophenyl)piperazine dihydrochloride (64090-19-3)

Guidance literature:

With sodium carbonate; In butan-1-ol;

DOI:10.1002/mrc.1641

Reference yield: 100.0%

1,3,5-trichloro-2,4,6-triazine (108-77-0) + 1-(4-fluorophenyl)piperazine dihydrochloride (64090-19-3) → 2,4-dichloro-6-[4-(4-fluorophenyl)piperazin-1-yl]-1,3,5-triazine

Guidance literature:

1,3,5-trichloro-2,4,6-triazine; With sodium carbonate; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

1-(4-fluorophenyl)piperazine dihydrochloride; In tetrahydrofuran; at 20 ℃; for 72h;

Reference yield: 92.2%

chloroform methanol (7285-11-2) + N-tert-butoxycarbonylphenylalanine p-nitrophenyl ester (19901-44-1) + 1-(4-fluorophenyl)piperazine dihydrochloride (64090-19-3) → 1,1-dimethylethyl 2-(4-(4-fluorophenyl)-1-piperazinyl)-2-oxo-1-(phenylmethyl)ethylcarbamate

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide;

upstream raw materials:

bis-(2-chloroethyl)amine hydrochloride

4-fluoroaniline

Downstream raw materials:

4-(3,5-Dimethyl-pyrazol-1-yl)-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-5H-pyridazino[4,5-b]indole

6-{4-[4-(4-fluoro-phenyl)-piperazin-1-ylmethyl]-phenoxy}-nicotinamide

(5S)-5-((1R)-4-(4-ethoxyphenyl)-1-{[4-(4-fluorophenyl)piperazin-1-yl]carbonyl}butyl)-2,2-dimethyl-1,3-dioxolan-4-one

4-((4-chloromethylphenyl)methyl)-1-(4-fluorophenyl)piperazine

Refernces