5-Fluorouridine

Base Information

• Chemical Name: 5-Fluorouridine
• CAS No.: 77180-80-4
• Molecular Formula: C₉H₁₁FN₂O₆
• Molecular Weight: 262.195
• Hs Code.: 2942000000
• Mol file: 77180-80-4.mol

Synonyms:5-Fluorouridine;

Chemical Property of 5-Fluorouridine

Chemical Property:

• Melting Point: 182-184 ºC
• Refractive Index: 1.641
• PKA: 7.65±0.10(Predicted)
• PSA: 124.78000
• Density: 1.77 g/cm³
• LogP: -2.71280
• Storage Temp.: 2-8°C
• Water Solubility.: soluble

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Fluorouridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 40
• Safety Statements: 22-26-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Fluorouridine

There total 2 articles about 5-Fluorouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C30H23FN2O9 (77180-97-3) → 5-Fluoro-1-((2R,3R,4R,5R)-3,4,5-trihydroxy-tetrahydro-pyran-2-yl)-1H-pyrimidine-2,4-dione (77180-80-4)

Guidance literature:

With sodium methylate; In methanol; Ambient temperature;

DOI:10.1135/cccc19803217

Reference yield:

1-(2',3',4'-tri-O-benzoyl-β-D-ribopyranosyl)uracil (58377-32-5) → 5-Fluoro-1-((2R,3R,4R,5R)-3,4,5-trihydroxy-tetrahydro-pyran-2-yl)-1H-pyrimidine-2,4-dione (77180-80-4)

Guidance literature:

Multi-step reaction with 2 steps

1: F₂, 5percent ethanolic triethylamine / acetic acid / 1 h / Ambient temperature

2: CH₃ONa / methanol / Ambient temperature

With sodium methylate; fluorine; triethylamine; In methanol; acetic acid;

DOI:10.1135/cccc19803217

upstream raw materials:

C₃₀H₂₃FN₂O₉

1-(2',3',4'-tri-O-benzoyl-β-D-ribopyranosyl)uracil

Refernces