(2-Formamido-1,3-thiazol-4-yl)glyoxylic acid

Base Information

• Chemical Name: (2-Formamido-1,3-thiazol-4-yl)glyoxylic acid
• CAS No.: 64987-06-0
• Molecular Formula: C6H4N2O4S
• Molecular Weight: 200.175
• Hs Code.: 2934100090
• European Community (EC) Number: 426-680-2,613-733-1
• DSSTox Substance ID: DTXSID70519250
• Wikidata: Q72479151
• Mol file: 64987-06-0.mol

Synonyms:2-(2-Formamido-4-thiazolyl)glyoxylicacid;2-(Formylamino)-a-oxo-4-thiazoleacetic acid;SQ 27710;

Chemical Property of (2-Formamido-1,3-thiazol-4-yl)glyoxylic acid

Chemical Property:

• Vapor Pressure: 2.43E-07mmHg at 25°C
• Refractive Index: 1.692
• Boiling Point: 406.6 ºC at 760 mmHg
• PKA: 1.80±0.54(Predicted)
• Flash Point: 199.7 ºC
• PSA: 124.60000
• Density: 1.739 g/cm³
• LogP: 0.68760
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 199.98917779
• Heavy Atom Count: 13
• Complexity: 245

Purity/Quality:

99.9% ^*data from raw suppliers

2-(2-Formamidothiazol-4-yl)-2-oxoaceticacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(N=C(S1)NC=O)C(=O)C(=O)O

Technology Process of (2-Formamido-1,3-thiazol-4-yl)glyoxylic acid

There total 5 articles about (2-Formamido-1,3-thiazol-4-yl)glyoxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.6%

2-(2-formylaminothiazol-4-yl)thioglyoxylic S-acid methyl ester → 2-(2-formylamino-1,3-thiazol-4-yl)glyoxylic acid (64987-06-0)

Guidance literature:

With sodium hydroxide; In water;

Reference yield:

ethyl 2-(2-formylimino-2,3-dihydrothiazol-4-yl)glyoxylate → 2-(2-formylamino-1,3-thiazol-4-yl)glyoxylic acid (64987-06-0) + 2-(2-formylimino-2,3-dihydro-1,3-thiazol-4-yl)glyoxylic acid

Guidance literature:

With sodium hydroxide; In water;

Reference yield:

ethyl 2-(2-formylaminothiazol-4-yl)glyoxylate (64987-03-7) → 2-(2-formylamino-1,3-thiazol-4-yl)glyoxylic acid (64987-06-0)

Guidance literature:

With hydrogenchloride; sodium hydroxide;

DOI:10.1021/jm00388a003

upstream raw materials:

ethyl 2-(2-formylaminothiazol-4-yl)glyoxylate

ethyl 2-(2-formylaminothiazol-4-yl)acetate

Downstream raw materials:

2-oxo-2-(2-aminothiazol-4-yl)acetic acid

2-(2-formamidothiazol-4-yl)-2-(4-aminomethylbenzyloxyimino)acetic acid

Refernces

• 1、 -. "Process for producing 2-(2-aminothiazol-4-yl)glyoxylic acid derivative or a salt thereof, and intermediates therefor and process for producing the intermediates". . . Retrieved 2008/06/13.
• 2、 -. "2-Lower alkyl-7-substituted amino-2 or 3-cephem-4-carboxylic acid compounds". . . Retrieved 2008/06/13.