Gemifloxacin mesylate

Base Information Edit

Chemical Name:Gemifloxacin mesylate
CAS No.:210353-53-0
Deprecated CAS:204519-65-3,214346-13-1
Molecular Formula:CH₄O₃S*C₁₈H₂₀FN₅O₄
Molecular Weight:485.493
Hs Code.:29339900
NSC Number:759252
UNII:X4S9F8RL01
DSSTox Substance ID:DTXSID7045948
NCI Thesaurus Code:C47548
RXCUI:402429
ChEMBL ID:CHEMBL1200621
Mol file:210353-53-0.mol

Synonyms:7-(3-aminomethyl-4-methoxyimino-pyrrolidine-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-(1,8)-naphthyridine-3-carboxylic acid;Factive;gemifloxacin;gemifloxacin mesylate;LB 20304;LB-20304;LB20304;SB 265805;SB-265805;SB265805

Suppliers and Price of Gemifloxacin mesylate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(Z)-GemifloxacinMesilate
50mg
$ 155.00

Medical Isotopes, Inc.
GemifloxacinMesilate
50 mg
$ 1880.00

Matrix Scientific
Gemifioxacin mesylate 95+%
250mg
$ 238.00

Matrix Scientific
Gemifioxacin mesylate 95+%
1g
$ 720.00

DC Chemicals
Gemifioxacin >98%
250 mg
$ 600.00

DC Chemicals
Gemifioxacin >98%
100 mg
$ 450.00

DC Chemicals
Gemifioxacin >98%
1 g
$ 1200.00

Crysdot
GemifloxacinMesylate 98+%
100mg
$ 119.00

Crysdot
GemifloxacinMesylate 98+%
50mg
$ 84.00

ChemScene
Gemifloxacinmesylate 99.84%
100mg
$ 204.00

Total 61 raw suppliers

Chemical Property of Gemifloxacin mesylate Edit

Chemical Property:

Appearance/Colour:beige solid
Melting Point:235-237 °C
Boiling Point:638.9 °C at 760 mmHg
Flash Point:340.2 °C
PSA：185.79000
LogP:2.31610
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:5
Exact Mass:485.13804746
Heavy Atom Count:33
Complexity:817

Purity/Quality:

99% ^*data from raw suppliers

(Z)-GemifloxacinMesilate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CON=C1CN(CC1CN)C2=C(C=C3C(=O)C(=CN(C3=N2)C4CC4)C(=O)O)F.CS(=O)(=O)O
Isomeric SMILES:CO/N=C/1\CN(CC1CN)C2=C(C=C3C(=O)C(=CN(C3=N2)C4CC4)C(=O)O)F.CS(=O)(=O)O
Recent EU Clinical Trials:A Phase IIIb, Randomized, Double-Blind, Multicenter, Parallel Group Study
Description Gemifloxacin is a new fluoroquinolone derivative that is active against both Grampositive and Gram-negative bacteria, and it was launched as an oral treatment for bacterial respiratory infections. Compared with other fluoroquinolones currently on the market, gemifloxacin possesses enhanced in vitro activity against Streptococcus pneumoniae, including isolates resistant to b-lactams, macrolides, and ciprofloxacin. Gemifloxacin is specifically indicated for treating community- acquired pneumonia (CAP) caused by multi-drug resistant S. pneumoniae and for treating acute bacterial exacerbations of chronic bronchitis (AECB). The recommended dose of gemifloxacin is 320 mg daily for 5 days for AECB and 320 mg daily for 7 days for CAP.
Uses Third generation fluorinated quinolone antibacterial.

Technology Process of Gemifloxacin mesylate

There total 7 articles about Gemifloxacin mesylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.1%