1-[(4-Hydrazinophenyl)methyl]-1H-1,2,4-triazole hydrochloride

Base Information

• Chemical Name: 1-[(4-Hydrazinophenyl)methyl]-1H-1,2,4-triazole hydrochloride
• CAS No.: 154748-67-1
• Molecular Formula: C₉H₁₁N₅*ClH
• Molecular Weight: 225.681
• Hs Code.: 2933990090
• Mol file: 154748-67-1.mol

Synonyms:1H-1,2,4-Triazole,1-[(4-hydrazinophenyl)methyl]-, monohydrochloride (9CI);[(4-1H-1,2,4-Triazol-1-ylmethyl)phenyl]hydrazinehydrochloride;1H-1,2,4-triazole, 1-[(4-hydrazinylphenyl)methyl]-, hydrochloride (1:1);1-(4-Hydrazinobenzyl)-1H-1,2,4-triazole hydrochloride (1:1);

Chemical Property of 1-[(4-Hydrazinophenyl)methyl]-1H-1,2,4-triazole hydrochloride

Chemical Property:

• Vapor Pressure: 6.96E-09mmHg at 25°C
• Boiling Point: 460.6 °C at 760 mmHg
• Flash Point: 232.3 °C
• PSA: 68.76000
• LogP: 2.18730
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

1-[(4-Hydrazinophenyl)methyl]-1H-1,2,4-triazoleHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-[(4-Hydrazinophenyl)methyl]-1h-1,2,4-triazole Hydrochloride is a useful reagent in the preparation of pyrazolylbenzyltriazoles as dual anti-inflammatory/antimicrobial agents and cyclooxygenase inhibitors.

Technology Process of 1-[(4-Hydrazinophenyl)methyl]-1H-1,2,4-triazole hydrochloride

There total 3 articles about 1-[(4-Hydrazinophenyl)methyl]-1H-1,2,4-triazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(1,2,4-triazol-1-yl-methyl)phenyl-diazonium chloride (1092370-41-6) → (4-[1,2,4]triazol-1-ylmethylphenyl)hydrazine hydrochloride (154748-67-1,212248-62-9)

Guidance literature:

4-(1,2,4-triazol-1-yl-methyl)phenyl-diazonium chloride; With triphenylphosphine; In methanol; diethyl ether; water; at 5 - 20 ℃; for 8h;

With hydrogenchloride; water; In methanol; diethyl ether; for 5h; Heating / reflux;

Reference yield:

4-(1,2,4-triazol-1-ylmethyl)phenylhydrazine (144035-22-3) → (4-[1,2,4]triazol-1-ylmethylphenyl)hydrazine hydrochloride (154748-67-1,212248-62-9)

Guidance literature:

With hydrogenchloride; In water; at 65 ℃; for 1 - 3h;

Reference yield:

4-(1H-1,2,4-triazol-1-ylmethyl)aniline (119192-10-8) → (4-[1,2,4]triazol-1-ylmethylphenyl)hydrazine hydrochloride (154748-67-1,212248-62-9)

Guidance literature:

4-(1H-1,2,4-triazol-1-ylmethyl)aniline; With hydrogenchloride; sodium nitrite; In water; at -10 - -2 ℃; for 1h;

With sodium sulfite; In water; at -15 - -10 ℃; for 0.5h;

With hydrogenchloride; In water; at 25 - 30 ℃; for 2h;

upstream raw materials:

4-(1,2,4-triazol-1-yl-methyl)phenyl-diazonium chloride

4-(1,2,4-triazol-1-ylmethyl)phenylhydrazine

4-(1H-1,2,4-triazol-1-ylmethyl)aniline

Downstream raw materials:

2-<5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl>ethylamine

Refernces

• 1、 -. "PROCESS FOR THE LARGE SCALE PRODUCTION OF RIZATRIPTAN BENZOATE". Page/Page column 5; 9. . Retrieved 2008/06/13.