7-Hydroxy-1-tetralone

Base Information

• Chemical Name: 7-Hydroxy-1-tetralone
• CAS No.: 22009-38-7
• Molecular Formula: C10H10O2
• Molecular Weight: 162.188
• Hs Code.: 2914400090
• European Community (EC) Number: 696-527-4
• DSSTox Substance ID: DTXSID00341263
• Nikkaji Number: J1.854.436I
• Wikidata: Q72481934
• Mol file: 22009-38-7.mol

Synonyms:7-Hydroxy-1-tetralone;22009-38-7;7-Hydroxy-3,4-dihydronaphthalen-1(2H)-one;7-hydroxy-3,4-dihydro-2H-naphthalen-1-one;7-Hydroxytetralin-1-one;MFCD01312225;7-Hydroxy-3,4-dihydro-1(2H)-naphthalenone;1(2H)-Naphthalenone, 3,4-dihydro-7-hydroxy-;7-hydroxytetralone;7-hydroxy-tetralone;7-Hydroxy-1-tetralone (5);SCHEMBL385554;DTXSID00341263;BDBM166645;AMY14181;BCP16590;AKOS006229303;CS-W022544;MB01768;AC-27437;AS-10078;SY045775;3,4-dihydro-7-hydroxy-1(2H)-naphthalenone;BB 0257319;FT-0648907;H1650;7-Hydroxy-3,4-dihydro-1(2H)-naphthalenone #;EN300-191143;A851740;7-HYDROXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-ONE;Z1198156579

Chemical Property of 7-Hydroxy-1-tetralone

Chemical Property:

• Vapor Pressure: 3.25E-05mmHg at 25°C
• Melting Point: 164.0 to 168.0 °C
• Refractive Index: 1.602
• Boiling Point: 344.7 °C at 760 mmHg
• PKA: 9.44±0.20(Predicted)
• Flash Point: 146.8 °C
• PSA: 37.30000
• Density: 1.236 g/cm³
• LogP: 1.91120
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 162.068079557
• Heavy Atom Count: 12
• Complexity: 188

Purity/Quality:

99.9% ^*data from raw suppliers

7-Hydroxy-1-tetralone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2=C(C=C(C=C2)O)C(=O)C1
• Uses: 7-Hydroxy-1-tetralone, its derivatives and related fluorescent chalcones have been used as pharmacological tools to study the human histamine H3 receptor. Also C7-Substituted α-Tetralone derivatives have been study as Inhibitors of Monoamine Oxidase.

Technology Process of 7-Hydroxy-1-tetralone

There total 14 articles about 7-Hydroxy-1-tetralone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

7-Methoxy-1-tetralone (6836-19-7) → 7-hydroxy-1-tetralone (22009-38-7)

Guidance literature:

With hydrogen bromide; acetic acid; In water; at 120 ℃;

Reference yield: 95.0%

bromohydric acid + 7-Methoxy-1-tetralone (6836-19-7) → 7-hydroxy-1-tetralone (22009-38-7)

Guidance literature:

With acetic acid;

Reference yield: 83.0%

1,7-Dihydroxynaphthalene (575-38-2) → 7-hydroxy-1-tetralone (22009-38-7)

Guidance literature:

With aluminum tri-bromide; cyclohexane; In various solvent(s); at 20 ℃; for 28h;

upstream raw materials:

7-Methoxy-1-tetralone

3,4-dihydronaphthalene-1(2H)-one

4a-acetoxy-5,6,7,8-tetrahydro-4aH-naphthalen-2-one

1,7-Dihydroxynaphthalene

Downstream raw materials:

7-(3,4-Dichlorobenzyloxy)-1-(4-methyl-1-piperazinyl)-naphthalene

7-(3-chlorobenzyloxy)-α-tetralone

7?(4?chlorobenzyloxy)?1?tetralone

7-(Pyridin-4-ylmethoxy)-1,2,3,4-tetrahydronaphthalen-1-one

Refernces

• 1、 Mosettig,May. "-". . p. 528,536. Retrieved 1940.
• 2、 Cloete, Stephanus J.,N’Da, Clarina I.,Legoabe, Lesetja J.,Petzer, Anél,Petzer, Jacobus P.. "The evaluation of 1-tetralone and 4-chromanone derivatives as inhibitors of monoamine oxidase". . p. 491 - 507. Retrieved 2020/10/02.
• 3、 -. "COMPOUNDS WITH A BENZO[A]CARBAZOLE STRUCTURE AND USE THEREOF". Page/Page column 39-40. . Retrieved 2019/04/10.