2,3-O-Isopropylidene-D-ribofuranoside

Base Information

• Chemical Name: 2,3-O-Isopropylidene-D-ribofuranoside
• CAS No.: 13199-25-2
• Molecular Formula: C8H14O5
• Molecular Weight: 190.196
• Hs Code.: 2932999099
• Mol file: 13199-25-2.mol

Synonyms:Ribose, 2,3-O-isopropylidene- (6CI,7CI);;Ribose, 2,3-O-isopropylidene-, D- (8CI);2,3-O-Isopropylidene-D-ribose;

Chemical Property of 2,3-O-Isopropylidene-D-ribofuranoside

Chemical Property:

• Appearance/Colour: Pale yellow oily liquid
• Vapor Pressure: 7.17E-06mmHg at 25°C
• Melting Point: ?8?°C(lit.)
• Refractive Index: 1.485
• Boiling Point: 337.426 °C at 760 mmHg
• PKA: 13.46±0.20(Predicted)
• Flash Point: 157.87 °C
• PSA: 68.15000
• Density: 1.267 g/cm³
• LogP: -0.78400
• Storage Temp.: 2-8°C
• Solubility.: Soluble in acetone.

Purity/Quality:

99% ^*data from raw suppliers

2,3-O-Isopropylidene-D-ribose ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C,Xi
• Hazard Codes: C,Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,3-O-Isopropylidene-alpha,beta-D-ribofuranose is used as a pharmaceutical intermediate.

Technology Process of 2,3-O-Isopropylidene-D-ribofuranoside

There total 3 articles about 2,3-O-Isopropylidene-D-ribofuranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

D-ribose (50-69-1) + acetone (67-64-1) → 2,3-O-Isopropylidene-D-ribose (13199-25-2)

Guidance literature:

With sulfuric acid;

DOI:10.1016/j.tetlet.2009.05.075

Reference yield:

D-ribose (50-69-1) + acetone (67-64-1) → 2,3-O-Isopropylidene-D-ribose (13199-25-2)

Guidance literature:

With sulfuric acid; copper(II) sulfate;

DOI:10.1016/S0008-6215(00)80921-0

Reference yield:

→ 2,3-O-Isopropylidene-D-ribose (13199-25-2)

Guidance literature:

1) 2,3-O-Isopropyliden-D-ribono-1,4-lacton, Natriumborhydrid u. Eg. in Ae.; 2) Aceton;

DOI:10.1139/v66-239

upstream raw materials:

D-ribose

acetone

Downstream raw materials:

C₂₄H₃₂O₅Si

(1R)-(-)-1-[(4R,5S)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl]-2-(tert-butyldiphenylsilyloxy)ethan-1-ol

5'-O-tert-butyldimethylsilyl-2,3-O-isopropylidene-D-ribose

(4R,5R)-2,2-dimethyl-5-vinyl-[1,3]dioxolane-4-carbaldehyde

Refernces

• 1、 Hulyalkar. "-". . p. 1594,1595. Retrieved 1966.
• 2、 Srihari,Sathish Reddy,Yadav,Yedlapudi,Kalivendi, Shasi V.. "First total synthesis and structure confirmation of diacetylenic polyol (+)-oploxyne B". supporting information. p. 5616 - 5618. Retrieved 2013/09/23.
• 3、 Navickas, Vaidotas,Maier, Martin E.. "Synthesis of the proposed structure of queenslandon". scheme or table. p. 94 - 101. Retrieved 2010/03/03.