Lovastatin Sodium

Base Information

• Chemical Name: Lovastatin Sodium
• CAS No.: 75225-50-2
• Molecular Formula: C24H37NaO6
• Molecular Weight: 444.54
• European Community (EC) Number: 641-623-3
• UNII: LK08RY63S3
• ChEMBL ID: CHEMBL175236
• Nikkaji Number: J428.164K
• Pharos Ligand ID: 7ULJ1KUN97MN
• Mol file: 75225-50-2.mol

Synonyms:L 154819;L-154,819;L-154819;lovestatin acid;mevinolinic acid;mevinolinic acid, (1S-(1alpha(betaS*,deltaS*),2alpha,6beta,8beta(R*),8aalpha))-isomer;mevinolinic acid, aluminum salt (3:1);mevinolinic acid, calcium salt (2:1);mevinolinic acid, monoammonium salt, 1S-(1alpha(betaS*),2alpha,6beta,8beta(R*),8aalpha)-isomer;mevinolinic acid, monosodium salt;mevinolinic acid, monosodium salt, (1S-(1alpha(betaS*,deltaS*),2alpha,6beta,8beta(R*),8aalpha))-isomer

Chemical Property of Lovastatin Sodium

Chemical Property:

• Vapor Pressure: 5.09E-17mmHg at 25°C
• Melting Point: 154-160 oC
• Boiling Point: 602.3°C at 760 mmHg
• Flash Point: 199.1°C
• PSA: 106.89000
• LogP: 2.38090
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 11
• Exact Mass: 444.24878318
• Heavy Atom Count: 31
• Complexity: 661

Purity/Quality:

98%Min ^*data from raw suppliers

LovastatinHydroxyAcid,SodiumSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC(CC(CC(=O)[O-])O)O)C.[Na+]
• Isomeric SMILES: CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@H](C[C@H](CC(=O)[O-])O)O)C.[Na+]
• Uses: A metabolite of Lovastatin Brimonidine Intermediate Lovastatin Hydroxy Acid, Sodium Salt (Lovastatin EP Impurity B) is a metabolite of Lovastatin.

Technology Process of Lovastatin Sodium

There total 1 articles about Lovastatin Sodium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

lovastatin (75330-75-5,79952-44-6) → lovastatin hydroxy acid sodium salt (75225-50-2)

Guidance literature:

With sodium hydroxide; water; at 50 ℃; for 2h;

Reference yield:

lovastatin hydroxy acid sodium salt (75225-50-2) + sildenafil citrate → sildenafil-lovastatinic acid complex salt

Guidance literature:

In ethanol; water; at 50 ℃; for 0.333333h;

upstream raw materials:

lovastatin

Refernces

• 1、 -. "Parmaceutical". Page/Page column 4. . Retrieved 2008/06/13.