2-Methoxyimidazoline

Base Information

• Chemical Name: 2-Methoxyimidazoline
• CAS No.: 28118-54-9
• Molecular Formula: C4H8N2O
• Molecular Weight: 100.12
• Hs Code.: 2933290090
• Mol file: 28118-54-9.mol

Synonyms:2-Imidazoline,2-methoxy- (6CI,8CI);2-Methoxy-2-imidazoline;Lys Tag 4H;

Chemical Property of 2-Methoxyimidazoline

Chemical Property:

• Appearance/Colour: White powder
• Melting Point: 70-72 °C
• Refractive Index: 1.562
• Boiling Point: 255.492 °C at 760 mmHg
• PKA: 8.53±0.40(Predicted)
• Flash Point: 108.318 °C
• PSA: 33.62000
• Density: 1.207 g/cm³
• LogP: -0.64360
• Storage Temp.: -20°C Freezer

Purity/Quality:

98%min ^*data from raw suppliers

4,5-Dihydro-2-methoxy-1H-imidazole,(30-40%solutioninDichloromethane) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Methoxyimidazoline is a multifunctional label for use in proteomics studies that is both lysine-specific and increases the overall sequence coverage obtained in peptide mapping experiments by increasing the ionization efficiences of lysine-terminated tryptic fragments. A labeling reagent for enhanced protein characterization with mass spectrometry. Contains approx. 1% ethyleneurea.

Technology Process of 2-Methoxyimidazoline

There total 3 articles about 2-Methoxyimidazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N,N'-ethylenethiourea (96-45-7) + methanol (67-56-1) → 2-methoxy-4,5-dihydro-1H-imidazole (28118-54-9)

Guidance literature:

With ozone; In dichloromethane; at 25 ℃;

DOI:10.1080/00397919608004633

Reference yield:

2-methylthioimidazoline (20112-79-2) → imidazolidone (120-93-4) + 2-methoxy-4,5-dihydro-1H-imidazole (28118-54-9)

Guidance literature:

With methanol; sodium methylate;

DOI:10.1021/jo01361a625

Reference yield:

2-methylthioimidazoline (20112-79-2) + sodium methylate (124-41-4) → 2-methoxy-4,5-dihydro-1H-imidazole (28118-54-9)

Guidance literature:

With methanol;

DOI:10.1021/jo01087a019

upstream raw materials:

2-methylthioimidazoline

sodium methylate

N,N'-ethylenethiourea

methanol

Downstream raw materials:

niridazole

Refernces

• 1、 Saladino, Raffaele,Crestini, Claudia,Occhionero, Francesca,Nicoletti, Rosario. "Ozonation of thioamide containing heterocycles. A new general and selective procedure for the synthesis of C-2 substituted heteroazole derivatives". . p. 3241 - 3251. Retrieved 2007/10/03.